The vicious cycle of SASP and inflammaging promotes aging and age-related diseases.

Qian Liu, Yulin Zheng, Chongkui Sun

Abstract readReview

In one paragraph

Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qian Liu *Department of Geriatrics, Institute of Geriatrics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Yulin Zheng *Department of Geriatrics, Institute of Geriatrics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Chongkui SunDepartment of Geriatrics, Institute of Geriatrics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. csun@uestc.edu.cn.ORCID 0000-0003-0362-4129

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81872207

6 · The paper itself

Abstract

Senescent cells accumulate in aging tissues and secrete a complex array of bioactive factors that alter the surrounding environment. While transient signaling can support tissue repair, persistent activity drives chronic low-grade inflammation and contributes to age-related diseases. These factors can spread damage to nearby cells and disrupt immune balance, creating a self-reinforcing cycle. We integrate these features into a three‑dimensional framework of duality, vicious cycle, and tissue specificity to guide context‑matched therapy. This review discusses how senescent cells influence tissue function during aging, the mechanisms underlying their harmful effects, and emerging strategies to limit these effects.

Indexed as

AgingCellular SenescenceInflammationSenescence-Associated Secretory PhenotypeAnimalsHumansSignal Transduction

Identifiers

PMID42722713

DOI10.1038/s42003-026-10826-4

PMCPMC13562716

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.