Evidence map›Paper›PMID 42722665›Full record

ArticleNature communications2026

Hypothalamic prolactin receptor

Ningrong Chen, Shreya Kumar, Kalp Patel, Shangqing Li, Mei Wan, Janet Crane, Xu Cao

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ningrong ChenCenter for Musculoskeletal Research, Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.ORCID http://orcid.org/0000-0001-7675-0826
Shreya KumarCenter for Musculoskeletal Research, Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.ORCID http://orcid.org/0009-0003-0519-3913
Kalp PatelCenter for Musculoskeletal Research, Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.ORCID http://orcid.org/0009-0008-5814-0037
Shangqing LiCenter for Musculoskeletal Research, Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
Mei WanCenter for Musculoskeletal Research, Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.ORCID http://orcid.org/0000-0001-9404-540X
Janet CraneCenter for Musculoskeletal Research, Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA.ORCID http://orcid.org/0000-0001-7713-0936
Xu CaoCenter for Musculoskeletal Research, Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MA, USA. xcao11@jhmi.edu.ORCID http://orcid.org/0000-0001-8614-6059

Funding

Skeleton and Joint Degeneration with AgingP01AG066603 · NIA · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2021 to 2025
$9.2M
Sialylation of TLR2 Induces Osteoclast Fusion and Th 17 differentiation During AgingR01AG076783 · NIA · JOHNS HOPKINS UNIVERSITY · PI Xu Cao · 2022 to 2026
$2.4M
Subchondral Bone Cavities in Osteoarthritis PainR01AG068997 · NIA · JOHNS HOPKINS UNIVERSITY · PI CAO, XU, GUAN, YUN · 2024 to 2024
$621k
NIA NIH HHS P01 AG066603NIA NIH HHS R01 AG068997NIA NIH HHS R01 AG076783U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01AG068997U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P01AG066603U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG076783
6 · The paper itself

Abstract

Women during lactation undergo significant bone loss and metabolic changes. However, the underlying mechanisms in the brain remain unclear. Herein, we found that prolactin receptor (PRLR)

Indexed as

Dopaminergic NeuronsEnergy MetabolismHypothalamusLactationNociceptionReceptors, ProlactinAnimalsArcuate Nucleus of HypothalamusCalciumFemaleMiceMice, Inbred C57BLNeuropeptide YParaventricular Hypothalamic NucleusProlactinSignal TransductionCalciumNeuropeptide YProlactinReceptors, ProlactinTyrosine 3-Monooxygenase

Identifiers

PMID42722665
PMCPMC13562519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.