ArticleNature communications2026
InsP3R signaling and actomyosin-dependent mitochondrial dynamics play essential roles in mitochondrial stress-induced longevity.
Gaomin Feng, Elizabeth M Ruark, Alexandra G Mulligan, Eric K F Donahue, Anthony L Hoang, Brianne Jacquet-Cribe, Li Peng, Kristopher Burkewitz
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Gaomin Feng *Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Elizabeth M Ruark *Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Anthony L HoangDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Brianne Jacquet-CribeDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Li PengDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MTargeting ER-mitochondrial calcium signaling to promote healthier agingR01AG073354 · NIA · VANDERBILT UNIVERSITY · PI Kristopher Burkewitz · 2022 to 2026
$1.6MTargeting mechanisms of inter-organelle communication to promote healthy agingR00AG052666 · NIA · VANDERBILT UNIVERSITY · PI BURKEWITZ, KRISTOPHER · 2019 to 2021
$726kNCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIA NIH HHS R00 AG052666NIA NIH HHS R01 AG073354NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIH HHS P40 OD010440U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R00AG052666U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG073354
6 · The paper itselfAbstract
Certain forms of mitochondrial impairment confer longevity, while disease-associated mitochondrial dysfunction triggers pathogenesis. The adaptive pathways that distinguish benefit from pathology remain unclear. Here we reveal that longevity induced by mitochondrial Complex I/nuo-6 mutation in C. elegans is dependent on the endoplasmic reticulum (ER) Ca
Indexed as
ActomyosinCaenorhabditis elegansInositol 1,4,5-Trisphosphate ReceptorsLongevityMitochondriaMitochondrial DynamicsAnimalsCaenorhabditis elegans ProteinsCalciumCalcium ChannelsEndoplasmic ReticulumMutationSignal TransductionStress, PhysiologicalActomyosinCaenorhabditis elegans ProteinsCalciumCalcium ChannelsInositol 1,4,5-Trisphosphate Receptorsmitochondrial calcium uniporter
Identifiers
PMID42722646
PMCPMC13562621
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