Evidence map›Paper›PMID 42722574›Full record

ReviewTrends in microbiology2026

Molecular pathways linking the gut microbiome to antitumor immunity.

Ximena Diaz-Olea, Amanda E Ramer-Tait, Jonathan E Cohen, Andrei Osterman, Zeev A Ronai

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ximena Diaz-OleaJim and Eleanor Randall Department of Surgery and the Department of Biomedical Sciences, Translational Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Amanda E Ramer-TaitDepartment of Food Science and Technology, Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Jonathan E CohenThe Angeles Clinic and Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90025, USA; Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel.
Andrei OstermanSanford Burnham Medical Discovery Institute, La Jolla, CA 92037, USA.
Zeev A RonaiJim and Eleanor Randall Department of Surgery and the Department of Biomedical Sciences, Translational Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: zeev.ronai@csmc.edu.

Funding

Rewired Signaling at the Nexus of Melanoma Metastasis and ResistanceR35CA283706 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Zeev A. Ronai · 2024 to 2026
$3.1M
NCI NIH HHS R35 CA283706
6 · The paper itself

Abstract

Accumulating evidence supports the important role played by the gut microbiota in controlling antitumor immune responses that impact tumor development. Extensive studies of bacterial species known to impact tumor growth have identified metabolites, produced by either bacteria or the host, that may alter efficacy of chemo- and/or immune-based therapies. Here, we summarize our current knowledge of those metabolites and the related bacterial species that influence activities linked with antitumor immunity, including epigenetic changes, the aryl hydrocarbon receptor signaling, cytokine and chemokine production, Janus kinase/signal transducer and activator of transcription signaling, and toll-like receptor signaling. We focus on specific metabolites, produced in the gut microbiome, which can alter molecular pathways associated with antitumor immunity, findings that warrant further evaluation in preclinical or clinical settings.

Indexed as

antitumor immunitymelanomametabolitesmolecular pathways

Identifiers

PMID42722574
PMCPMC13565589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.