Evidence map›Paper›PMID 42722433›Full record

ArticleGenes & development2026

Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity.

Mohamed E Ashour, Ellissa Krekeler, Monika Chandan Bhowmik, Holland Kantar, Ning Tsao, Carlos Herrera-Montávez, Miaw-Sheue Tsai, Manal Zaher, Lyudmila Y Kadyrova, Farid A Kadyrov and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Mohamed E AshourDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Ellissa KrekelerDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Monika Chandan BhowmikDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Holland KantarDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Ning TsaoDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Carlos Herrera-MontávezDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Miaw-Sheue TsaiBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Manal ZaherDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Lyudmila Y KadyrovaDivision of Biochemistry and Molecular Biology, Department of Biomedical Sciences, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA.
Farid A KadyrovDivision of Biochemistry and Molecular Biology, Department of Biomedical Sciences, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA.
Roberto GallettoDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Nima MosammaparastDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA; nmosammaparast@mdanderson.org.ORCID http://orcid.org/0000-0001-5453-5914

Funding

An RNA-Dependent Innate Immune Response Pathway to Base-Damaging ChemotherapeuticsR01CA282733 · NCI · WASHINGTON UNIVERSITY · PI Nima Mosammaparast · 2024 to 2026
$1.5M
Novel mechanisms in DNA mismatch repairR01GM132128 · NIGMS · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI KADYROV, FARID · 2020 to 2023
$1.2M
RNA damage induced DNA breaks: A new mechanism of genome instabilityR01GM160854 · NIGMS · WASHINGTON UNIVERSITY · PI MOSAMMAPARAST, NIMA · 2025 to 2025
$855k
NCI NIH HHS R01 CA282733NIGMS NIH HHS R01 GM132128NIGMS NIH HHS R01 GM160854
6 · The paper itself

Abstract

Alkylation chemotherapy is commonly used against tumors such as glioblastoma, yet resistance often develops through downregulation of mismatch repair (MMR). Previous work has established that loss of MMR prevents the excision of the thymine-containing strand across

Indexed as

alkylation damagebase excision repairDNA repairmismatch repair

Identifiers

PMID42722433

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.