ArticleBone & joint open2026
Clinical characteristics and risk factors of recurrence for Pseudomonas aeruginosa-associated fracture-related infection following surgical treatment : a 12-year retrospective cohort study.
Article in Bone & joint open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: Methods: This retrospective cohort study examined 147 cases of PA-FRI involving limb fractures treated at our centre from January 2012 to December 2023. Demographic, microbiological, and clinical parameters were evaluated with ≥ 24-month follow-up. Multivariate regression analysis was conducted to identify risk factors for recurrence. Results: The cohort (mean age 45.06 years (SD 13.83)) showed a predominance of tibial fractures (69.4%; 102 out of 147). MDR-PA prevalence increased from 33.3% (2012 to 2014) to 58.6% (2021 to 2023), accounting for 44.9% (n = 66) of isolates. Coinfection with Conclusion: The high MDR prevalence and recurrence rates underscore persistent challenges in PA-FRI. This study identifies key modifiable risk factors and establishes a risk-stratified framework to guide preoperative optimization, antimicrobial stewardship, and surgical decision-making.
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