Evidence map›Paper›PMID 42721965›Full record

ArticleNeuron2026

Cell-type-specific disruption of nucleus accumbens social representations in a mouse model of autism.

Pingping Zhao, Xing Chen, Arash Bellafard, Avaneesh Murugesan, Jonathan Quan, Daniel Aharoni, Peyman Golshani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pingping ZhaoDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Xing ChenDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Arash BellafardDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Avaneesh MurugesanDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jonathan QuanDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Daniel AharoniDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Peyman GolshaniDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Greater Los Angeles Veteran Affairs Medical Center, Los Angeles, CA, USA; Intellectual and Developmental Disabilities Research Center, University of California, Los Angeles, Los Angeles, CA, USA; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: pgolshani@mednet.ucla.edu.

Funding

The Role of Striosome Neurons in Mediating Opiod RewardP50DA005010 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WALWYN, WENDY M · 1987 to 2021
$30.7M
UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani, SUMA JACOB · 2020 to 2026
$9.6M
Hippocampal neural dynamics driving affiliation and attachmentUF1NS122124 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONALDSON, ZOE REBECCA, GOLSHANI, PEYMAN · 2021 to 2021
$4.8M
Unstable nucleus accumbens social representations in models of social behavioral dysfunction.R01MH132736 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani, Weizhe Hong · 2023 to 2026
$3.1M
Closed-Loop Systems for Large Scale Spatiotemporal Imaging and Actuation of Neural Activity in Freely Behaving AnimalsU01NS126050 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AHARONI, DANIEL, BLAIR, HUGH T · 2022 to 2025
$2.6M
NICHD NIH HHS P50 HD103557NIDA NIH HHS P50 DA005010NIMH NIH HHS R01 MH132736NINDS NIH HHS U01 NS126050NINDS NIH HHS UF1 NS122124
6 · The paper itself

Abstract

How cell-type-specific nucleus accumbens (NAc) circuits encode social interactions, and whether this encoding is disrupted in autism spectrum disorder (ASD), remains unresolved. Using longitudinal miniscope calcium imaging and optogenetics in mice, we show that NAc core population activity selectively encodes social interaction and that NAc inhibition enhances sociability. In Cntnap2

Indexed as

autismCntnap2(−/−)D1-MSNsD2-MSNsminiscope imagingnucleus accumbenssocial interactionsocial representation

Identifiers

PMID42721965
PMCPMC13608005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.