Different patterns of activated partial thromboplastin time (APTT) clot waveforms predicting the presence of lupus anticoagulant.

Kazutoshi Ebisawa, Masaki Tanibuchi, Kunitoshi Fukasawa, Takahiro Takeuchi

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Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Kazutoshi EbisawaDepartment of Hematology, Shizuoka Saiseikai General Hospital, 1-1 Oshika, Suruga-ku, Shizuoka, Japan. Electronic address: k181251@siz.saiseikai.or.jp.

Masaki TanibuchiDepartment of Laboratory medicine, Shizuoka Saiseikai General Hospital, 1-1 Oshika, Suruga-ku, Shizuoka, Japan.

Kunitoshi FukasawaDepartment of Laboratory medicine, Shizuoka Saiseikai General Hospital, 1-1 Oshika, Suruga-ku, Shizuoka, Japan.

Takahiro TakeuchiDepartment of Hematology, Shizuoka Saiseikai General Hospital, 1-1 Oshika, Suruga-ku, Shizuoka, Japan.

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6 · The paper itself

Abstract

introductionAtypical peak pattern in second derivative curve of clot wave of Activated Partial Thromboplastin Time (APTT) was known to be associated with presence of Lupus Anticoagulant (LA), but clinical significance of other abnormal patterns was uncertain.

methodWe retrospectively reviewed second derivative curves of clot waves of 271 samples with prolonged APTT (> 50 sec). These were approximated by fifth-order functions using polynomial regression analysis, and Principal Component Analysis (PCA) was performed to classify these functions.

resultsPCA analysis could separate a cluster of abnormal waveforms from that of normal pattern. Abnormal waveforms could be classified into atypical peak pattern, S-shaped pattern and Left Bundle Branch Block (LBBB)-like pattern, which formed discrete clusters on the PCA plot. While only a small proportion of cases with normal pattern were positive for LA (8/202 cases), all of these abnormal patterns were associated with LA (5/23, 9/27, 4/19 cases, respectively). DISCUSSION: Our analysis demonstrated that as well as atypical peak pattern, S-shaped and LBBB-like patterns could predict the presence of LA in cases with prolonged APTT.

Indexed as

Antiphospholipid syndromeAPTTClot wave analysisClot waveformLupus anticoagulant

Identifiers

PMID42721776

DOI10.1016/j.clinsp.2026.101136

PMCPMC13586575

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