Evidence map›Paper›PMID 42721423›Full record

Observational studyJournal of medical Internet research2026

Internet-Delivered Cognitive Behavioral Therapy for Social Anxiety Disorder: Nationwide Retrospective Cohort Observational Study.

Anna Paula Laizane, Ville Ritola, Tom H Rosenström, Suoma Eeva Saarni, Maya L Rutan, Boris Karpov, Satu Pihlaja, Jan-Henry Stenberg, Grigori Joffe

Abstract readObservational Study
In one paragraph

Observational study in Journal of medical Internet research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna Paula Laizane *Riga Stradiņš University and National Center for Mental Health, Riga, Latvia.ORCID http://orcid.org/0009-0001-7276-5569
Ville Ritola *Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0001-9065-4347
Tom H Rosenström *Department of Psychiatry, Faculty of Medicine, University of Helsinki, P.O. Box 3 (Fabianinkatu 33), Helsinki, Uusimaa, 00014, Finland, 358 40 5136500.ORCID http://orcid.org/0009-0008-3985-0754
Suoma Eeva Saarni *Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3555-9958
Maya L RutanUndergraduate Program in Neuroscience and Faculty of Computing & Data Sciences, Boston University, Boston, MA, United States.ORCID http://orcid.org/0009-0003-9598-7206
Boris Karpov *Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3647-2889
Satu Pihlaja *Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0002-2402-6956
Jan-Henry Stenberg *Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0003-1327-7757
Grigori Joffe *Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0002-0782-6812

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Internet-delivered cognitive behavioral therapies (iCBTs) can address the accessibility and affordability limitations of conventional therapy. Although iCBTs for social anxiety disorder (SAD) are efficacious, their effectiveness in routine care remains less well established. Helsinki University Hospital (HUS) provides a novel nationwide iCBT program for SAD. Objective: We aimed to assess whether this 7-session, flexible time-scheduled, therapist-supported HUS-iCBT for SAD, delivered by a specialized clinic, (1) is effective in routine care and (2) can enhance adherence, compared to previously published programs with ≥9 sessions. Methods: This retrospective, registry-based, observational cohort study used data from the HUS-iCBT register from 2019 to 2022. For treatment, the inclusion criteria were a diagnosis of SAD and possession of an email address and an official e-identification. Severe personality disorders, suicidal behavior, acute psychosis or mania, and disorders with cognitive decline were exclusion criteria. Altogether, 2360 physician-referred patients were accepted for therapy. For the study, we applied an additional criterion of ≥21 baseline score on the Social Phobia Inventory (SPIN, primary outcome) to verify the exclusion of subclinical conditions. Patients aged less than 18 years, with missing baseline information, who did not log-in, or reentered treatment were excluded. The remaining patients (n=1654) formed the modified intent-to-treat (mITT) population, provided they completed ≥1 on-therapy sessions. Secondary measures were Overall Anxiety Severity and Impairment Scale and Patient Health Questionnaire-9. Results: Linear mixed effects modeling revealed a large SPIN-measured effect size for mITT and completer populations (Cohen Conclusions: The innovative 7-session HUS-iCBT for SAD (vs ≥9 sessions in most previous programs) may improve adherence without compromising effectiveness. Task shifting from highly specialized to less specialized professionals may further improve cost-effectiveness, although formal health-economic evaluation is needed. These findings may inform the development of future iCBT programs for mental disorders.

Indexed as

Cognitive Behavioral TherapyInternetPhobia, SocialAdultFemaleFinlandHumansMaleMental Health TeletherapyMiddle AgedRetrospective Studiescognitive behavioral therapydigital healthiCBTinternetmental healthroutine caresocial anxiety disorderweb-based

Identifiers

PMID42721423
PMCPMC13561402

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.