Evidence map›Paper›PMID 42721220›Full record

ArticlePLoS computational biology2026

Analysis of multicellular anatomical structures from spatial omics data using sosta.

Samuel Gunz, Helena L Crowell, Mark D Robinson

Abstract read
In one paragraph

Article in PLoS computational biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samuel GunzDepartment of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-8909-0932
Helena L CrowellCentro Nacional de Análisis Genómico, Barcelona, Spain.
Mark D RobinsonDepartment of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-3048-5518

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatial omics technologies enable high-resolution, large-scale quantification of molecular features while preserving the spatial context within tissues. Existing analysis methods largely focus on spatial arrangements of single cells, whereas biological function often emerges from multicellular arrangements. Here, we introduce structure-based analysis of spatial omics data, which focuses on the direct analysis of multicellular, anatomical structures. We illustrate this type of analysis using two publicly available datasets and provide sosta, an open-source Bioconductor package for broad community use.

Indexed as

Computational BiologyGenomicsSoftwareAnimalsHumansSpatial Transcriptomics

Identifiers

PMID42721220
PMCPMC13607871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.