ArticleTherapeutic advances in respiratory disease
Association between systemic immune-inflammation index and in-hospital mortality in ICU patients with aspiration pneumonia: A retrospective cohort study based on MIMIC-IV database.
Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundAspiration pneumonia is a common and life-threatening condition among critically ill patients, with mortality reaching 20-50%. The Systemic Immune-Inflammation Index (SII), derived from the routine complete blood count, has shown prognostic value in various inflammatory and infectious diseases, but its association with outcomes in ICU patients with aspiration pneumonia is unknown.ObjectivesTo investigate the association between SII and in-hospital mortality in ICU patients with aspiration pneumonia and to characterize the dose-response relationship.DesignRetrospective cohort study using a large publicly available critical care database.MethodsAdult patients (≥18 years) admitted to the ICU with aspiration pneumonia and an ICU stay ≥24 hours were identified in the MIMIC-IV database (version 3.1). SII (neutrophil × platelet/lymphocyte count) was derived from laboratory values obtained within the first 24 hours of admission and stratified into quartiles. Multivariable logistic regression with sequential adjustment evaluated the association with in-hospital mortality; restricted cubic splines characterized the dose-response relationship, and subgroup and sensitivity analyses assessed robustness.ResultsA total of 2,132 patients were included (median age 66 years, IQR 54-78; 62.2% male); overall in-hospital mortality was 25.5%. Mortality across SII quartiles was 24.6% (Q1), 20.5% (Q2), 26.1% (Q3) and 31.0% (Q4), exhibiting a U-shaped pattern. Using Q2 as reference, the highest quartile was independently associated with increased mortality (adjusted OR 1.53, 95% CI 1.14-2.06; P=0.005), and restricted cubic spline analysis confirmed a non-linear U-shaped relationship (P for trend = 0.003). Results were consistent after additional adjustment for vasopressor use and mechanical ventilation (adjusted OR 1.70, 95% CI 1.11-2.60; P=0.014) and across age, sex and comorbidity subgroups, with no significant interactions.ConclusionIn ICU patients with aspiration pneumonia, SII showed a U-shaped association with in-hospital mortality. Pending prospective and external validation, SII may represent a promising candidate biomarker for risk stratification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.