ArticleJournal of cancer survivorship : research and practice2026
Association between daily step counts and frailty trajectory classes in lung cancer patients undergoing radiotherapy: a prospective longitudinal study.
Article in Journal of cancer survivorship : research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo characterize frailty trajectories in patients undergoing radiotherapy with lung cancer, identify factors associated with trajectory membership, and examine the association between daily step counts and frailty trajectories during radiotherapy.
methodsIn this prospective longitudinal study, daily step counts were collected via the WeChat Step Mini-program from the start to the end of radiotherapy. Frailty was assessed via the Frailty Phenotype Scale before radiotherapy, at the end of radiotherapy, and 1 month after radiotherapy. Latent class growth modeling was used to identify frailty-trajectory classes, and multinomial logistic regression was used to examine associated factors and the relationship between step counts and trajectory membership.
resultsAmong 327 patients, three frailty trajectories were identified: prefrailty declining (56.58%), frailty stable increasing (27.83%), and severe frailty increasing (15.60%) group. After adjustment for demographic and clinical covariates, higher average daily step counts during radiotherapy were independently associated with a lower likelihood of membership in adverse frailty trajectories.
conclusionsFrailty trajectories in patients with lung cancer undergoing radiotherapy were heterogeneous. Step-count gradients were observed around 3000, 6000, and 9000 steps/day, suggesting exploratory thresholds for different frailty-risk intervals. IMPLICATIONS FOR CANCER SURVIVORS: Daily step counts are a scalable real-world metric. Combining continuous step monitoring with routine frailty screening may support early identification of high-risk patients and proactive, individualized management during and after radiotherapy.
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