Evidence map›Paper›PMID 42720803›Full record

Observational studyJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2026

Preoperative predictors of low flow limit controller configuration following HeartMate 3 implantation.

Hiroshi Nishioka, Takuma Sato, Megumi Komiyama, Koki Iwanaga, Kohei Tonai, Nana Kitahata, Yuzo Takahashi, Sachie Miyagawa, Kazuya Sawada, Hideki Yotsuida and 5 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hiroshi NishiokaDepartment of Clinical Engineering, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Takuma SatoDepartment of Transplant medicine, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan. takuma.sato@ncvc.go.jp.
Megumi KomiyamaDepartment of Clinical Engineering, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Koki IwanagaDepartment of Clinical Engineering, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Kohei TonaiDepartment of Cardiovascular Surgery, Osaka University Hospital, Suita, Osaka, Japan.
Nana KitahataDepartment of Transplant medicine, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Yuzo TakahashiDepartment of Clinical Engineering, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Sachie MiyagawaDepartment of Clinical Engineering, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Kazuya SawadaDepartment of Apparel Design, Osaka Seikei College, Osaka, Osaka, Japan.
Hideki YotsuidaDepartment of Small Animal Clinical Sciences, University of Florida, Gainesville, USA.
Naoki TadokoroDepartment of Cardiovascular Surgery, Institute of Science Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Satsuki FukushimaDepartment of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Tomoyuki FujitaDepartment of Cardiovascular Surgery, Institute of Science Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Toshia FujisatoDepartment of Chemical, Environmental and Biomedical Engineering, Graduate School of Engineering, Osaka Institute of Technology, Suita, Osaka, Japan.
Yasumasa TsukamotoDepartment of Transplant medicine, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.

Funding

JMS Co., Ltd. JMS Co., Ltd.
6 · The paper itself

Abstract

This study aimed to identify preoperative factors associated with postoperative replacement to a controller configured with a Low Flow Limit (LFL) of 2.0 L/min following HeartMate 3 (HM3) left ventricular assist device (LVAD) implantation, with the goal of establishing proactive selection criteria to improve patient safety and quality of life (QOL). This single-center, retrospective, observational study included 127 patients who underwent primary HM3 implantation between June 2019 and March 2025. Patients were divided into those who maintained the standard LFL of 2.5 L/min controller throughout follow-up (Standard group, n = 78) and those who required postoperative replacement with a controller configured with an LFL of 2.0 L/min (2.0-LFL group, n = 49). Preoperative clinical, laboratory, echocardiographic, and hemodynamic parameters were compared using univariate and multivariate logistic regression analyses, together with receiver operating characteristic (ROC) curve analysis. 2.0-LFL group had significantly lower anthropometric indices, including height, weight, body mass index, and body surface area (BSA), as well as a shorter duration of heart failure, compared with Standard group. Although multiple clinical, echocardiographic, and hemodynamic variables were evaluated, multivariate analysis identified BSA as the sole independent predictor of postoperative controller replacement (odds ratio: 0.03; 95% confidence interval: 0.00-0.60; p = 0.022). ROC curve analysis demonstrated that a preoperative BSA cutoff value of 1.43 m

Indexed as

Heart-Assist DevicesHeart FailureBody Surface AreaFemaleHemodynamicsHumansMaleMiddle AgedPreoperative PeriodQuality of LifeRetrospective StudiesBody surface areaHeartMate 3Left ventricular assist deviceLow-flow alarm

Identifiers

PMID42720803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.