Evidence map›Paper›PMID 42720779›Full record

ArticleSurgery today2026

Feasibility and safety of intravenous tolvaptan administration immediately upon ICU admission after cardiac surgery with cardiopulmonary bypass.

Masahiko Narita, Kentaro Shirakura, Eijiro Hikasa, Hana Fukuta, Yuya Tamaru, Tomoki Nakatsu, Takayuki Kadohama, Nobuyuki Akasaka, Hiroyuki Kamiya

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Masahiko NaritaDepartment of Cardiovascular Surgery, Steel Memorial Muroran Hospital, Chiribetsucho 1-45, Muroran, 050-0076, Japan.
Kentaro ShirakuraDepartment of Cardiac Surgery, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, Japan. kyokui140021@gmail.com.
Eijiro HikasaDepartment of Cardiovascular Surgery, Steel Memorial Muroran Hospital, Chiribetsucho 1-45, Muroran, 050-0076, Japan.
Hana FukutaDepartment of Cardiovascular Surgery, Steel Memorial Muroran Hospital, Chiribetsucho 1-45, Muroran, 050-0076, Japan.
Yuya TamaruDepartment of Cardiovascular Surgery, Steel Memorial Muroran Hospital, Chiribetsucho 1-45, Muroran, 050-0076, Japan.
Tomoki NakatsuDepartment of Cardiovascular Surgery, Steel Memorial Muroran Hospital, Chiribetsucho 1-45, Muroran, 050-0076, Japan.
Takayuki KadohamaDepartment of Cardiovascular Surgery, Steel Memorial Muroran Hospital, Chiribetsucho 1-45, Muroran, 050-0076, Japan.
Nobuyuki AkasakaDepartment of Cardiovascular Surgery, Kushiro Kojinkai Memorial Hospital, Aikoku, Kushiro, 191-212, 085-0062, Japan.
Hiroyuki KamiyaDepartment of Cardiac Surgery, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTolvaptan sodium phosphate (TSP; Samtas

methodsWe enrolled 91 patients who underwent cardiac surgery with cardiopulmonary bypass at our institution. Of these, 46 received TSP immediately after intensive care unit admission, and 45 served as controls. After propensity score matching, 20 matched pairs were analyzed. A subgroup analysis was performed according to the renal function in TSP-treated patients.

resultsIn the propensity score-matched cohort, the TSP group showed a trend toward adequate early postoperative urine output and a gradual negative fluid balance. Regarding safety, electrolyte abnormalities did not increase in the TSP group. No patient in either group developed significant acute kidney injury. Similar trends were observed in patients with a reduced renal function.

conclusionsIn this selected cohort, intravenous TSP administration immediately upon ICU admission after cardiac surgery with cardiopulmonary bypass was feasible and not associated with any major safety concerns, including in patients with a reduced renal function. TSP also tended to reduce day-to-day fluid balance fluctuations with an adequate urine output.

Indexed as

Cardiac surgeryDiureticsFluid managementPostoperative managementTolvaptan sodium phosphate

Identifiers

PMID42720779

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