ArticlePsychopharmacology2026
Concurrent chronic methamphetamine exposure may influence behavioral outcomes following repetitive mild traumatic brain injury.
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
rationaleTraumatic brain injury (TBI) and substance use disorder (SUD) share several characteristics, including neurological outcomes and pathological traits. Misuse of stimulants, both non-prescription use of medications and illicit use of methamphetamine, is rising. Despite potential for misuse, stimulants are prescribed as treatment for some TBI-induced symptoms. Given that 40% of TBI patients have a history of SUD prior to injury, studies of the role that chronic substance misuse plays on the deleterious outcomes of TBI are warranted.
objectivesOur study explores the role that chronic methamphetamine exposure plays in the acute and long-term behavioral outcomes of repetitive mild TBI (rmTBI). We hypothesized that chronic methamphetamine exposure would exacerbate the behavioral deficits induced by rmTBI.
methodsWe developed a model combining non-contingent dosing of methamphetamine with the Closed Head Model of Engineered Rotational Acceleration (CHIMERA). Behavioral assays were employed one month after the final TBI to assess short-term effects and were repeated six months following the final TBI for long-term effects.
resultsThe Loss of Righting Reflex showed that chronic methamphetamine exposure impacted neither TBI severity nor immediate recovery. The T-maze and NORT revealed that rmTBI concurrent to chronic methamphetamine exposure induced short- and long-term cognitive deficits. Methamphetamine negatively impacted balance and coordination on the accelerated rotarod at the later timepoint only.
conclusionsTogether, these findings suggest that chronic methamphetamine exposure could potentially increase long-term, but not acute, TBI-induced deficits.
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