ReviewMikrochimica acta2026
Recent advances in MOF-phosphate interaction-based bioanalysis: from enrichment to sensing.
Review in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Molecular recognition serves as the foundation of bioanalytical strategies. Typical recognition mechanisms include antigen-antibody binding, biotin-streptavidin interaction, aptamer-target pairing, lectin-saccharide recognition, and the chelation of metal ions with phosphate groups, among others. Among these, the chelation of metal-organic frameworks (MOFs) with phosphate groups has emerged as a particularly concise and efficient molecular recognition strategy. In recent years, MOF-phosphate interactions have been extensively exploited in diverse bioanalytical platforms, highlighting their remarkable potential for practical applications. In this review, we summarize MOF-phosphate-based bioanalytical strategies, with a focus on their use in the enrichment of phospholipids and phosphopeptides, kinase activity assays, and the detection of various phosphate-containing analytes. Furthermore, we discuss the development of multifunctional MOF composites enabled by this interaction and conclude with perspectives on the opportunities and challenges that lie ahead.
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