Evidence map›Paper›PMID 42720403›Full record

ArticleBioanalysis

Evaluation of volumetric DBS for lead analysis using ICP-MS/MS: addressing matrix effects and hematocrit variability.

Halimat S Olaniyan, Joshua Kocemba, Gillian Coultas, John O Ogunbileje, Kavita Umrau, Michelle K Zimmerman, Rejwi A Dahal

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioanalysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Halimat S OlaniyanDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Joshua KocembaDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Gillian CoultasDivision of Clinical Chemistry, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
John O OgunbilejeDivision of Clinical Chemistry, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Kavita UmrauDivision of Hematopathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Michelle K ZimmermanDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Rejwi A DahalDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLead testing in dried blood spots (DBS) offer a convenient alternative to venous blood draw; however, its adoption has been limited by variable extraction efficiency, matrix effects, and hematocrit-dependent recovery. To mitigate these challenges, we explored the utility of volumetric DBS (vDBS) cards, which are known to deposit a fixed volume of blood that gets analyzed. MATERIALS AND

methodsSamples (quality control, proficiency testing, lead spiked, and patient samples that were positive for lead) were pipetted onto the backs of vDBS cards. Extracts were analyzed using Inductively Coupled Plasma-Tandem Mass Spectrometry in collision/reaction cell mode with oxygen gas. Deming regression analyses evaluated whole blood and vDBS analyzed with aqueous calibrators; vDBS analyzed with aqueous and DBS calibrators. Samples with varying hematocrit were assessed for impact on recovery.

resultsA comparison of vDBS cards (

conclusionvDBS can be analyzed without matrix-matched calibrators to simplify routine assessment.

Indexed as

Dried Blood Spot TestingLeadTandem Mass SpectrometryHematocritHumansLeadDried blood spothematocritinductively coupled mass spectrometryleadmatrix matchingvolumetric microsampling

Identifiers

PMID42720403
PMCPMC13644592

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.