ArticleChemistry & biodiversity2026
Phytochemical Profiling and Evaluation of Antibacterial, Anticancer, Anti-inflammatory, and Wound-Healing Activities of Endophytic Fungi Isolated From Atalantia racemosa.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Endophytic fungi are recognized as prolific sources of structurally diverse secondary metabolites with significant pharmaceutical potential. In the present study, endophytic fungi were isolated from healthy tissues of Atalantia racemosa (Rutaceae), an ethnomedicinal plant traditionally used for respiratory disorders and blood purification. A total of three fungal isolates were obtained and identified as Aspergillus flavus, Pleosporales sp., and Endothia sp. based on morphological and molecular (ITS sequencing) analyses. Crude extracts of the isolates were subjected to phytochemical characterization using GC-MS, FTIR, and LC-MS techniques. GC-MS profiling revealed the presence of fatty acids, sterols, phenolics, and terpenoids, while FTIR analysis confirmed key functional groups such as hydroxyl, carbonyl, and aromatic moieties. Importantly, LC-MS analysis provided high-resolution metabolite profiling, identifying diverse bioactive compounds including alkaloids, flavonoids, quinic acid derivatives, xanthones (mangostin derivatives), phenolic amides (N-feruloyl-octopamine), diterpenoids, chalcones, macrolides, and terpene lactones in both positive and negative ionization modes. Biological evaluation demonstrated notable antioxidant, antibacterial, anti-inflammatory, anticancer, and wound healing activities, with Endothia sp. showing superior anticancer activity (IC
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