Evidence map›Paper›PMID 42720095›Full record

ArticleChemistry & biodiversity2026

Clean Synthesis of N-4-Alkylamino-7-chloroquinoline Cyclic Imides: Influence of Lipophilicity on Antibacterial and Ecotoxicological Properties.

Agenor P Luz-Filho, Thais C Silva, Matheus B Silva, Abraão P Sousa, Helivaldo D S Souza, Priscila S V Lima, Alexandre Almeida-Júnior, Fábio C Sampaio, Petrônio F Athayde-Filho, Gabriela F Fiss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Agenor P Luz-FilhoLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Universidade Federal da Paraíba (UFPB), João Pessoa, Brazil.ORCID https://orcid.org/0009-0009-5750-1934
Thais C SilvaLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Universidade Federal da Paraíba (UFPB), João Pessoa, Brazil.ORCID https://orcid.org/0009-0002-5338-2201
Matheus B SilvaLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Universidade Federal da Paraíba (UFPB), João Pessoa, Brazil.ORCID https://orcid.org/0009-0004-5451-2498
Abraão P SousaLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Universidade Federal da Paraíba (UFPB), João Pessoa, Brazil.ORCID https://orcid.org/0009-0005-6585-2866
Helivaldo D S SouzaLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Universidade Federal da Paraíba (UFPB), João Pessoa, Brazil.ORCID https://orcid.org/0000-0002-1708-4066
Priscila S V LimaNúcleo de Química de Heterociclos (NUQUIMHE), Department of Chemistry, Universidade Federal de Santa Maria, Santa Maria, Brazil.ORCID https://orcid.org/0000-0002-6731-4333
Alexandre Almeida-JúniorLaboratório De Biologia Bucal (LABIAL), Department of Clinical and Community Dentistry, UFPB, João Pessoa, Brazil.ORCID https://orcid.org/0000-0002-9205-5230
Fábio C SampaioLaboratório De Biologia Bucal (LABIAL), Department of Clinical and Community Dentistry, UFPB, João Pessoa, Brazil.ORCID https://orcid.org/0000-0003-2870-5742
Petrônio F Athayde-FilhoLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Universidade Federal da Paraíba (UFPB), João Pessoa, Brazil.ORCID https://orcid.org/0000-0003-0982-8261
Gabriela F FissLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Universidade Federal da Paraíba (UFPB), João Pessoa, Brazil.ORCID https://orcid.org/0000-0001-8156-2272

Funding

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO 404927/2023-8COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR
6 · The paper itself

Abstract

Motivated by the promising antimicrobial and ecotoxicological effects of 4-alkylamino-7-chloroquinoline and N-alkylphthalimide derivatives, these privileged nuclei were linked to investigate how lipophilicity influences antibacterial activity and ecotoxicity. For this purpose, seven 4-alkylamino-7-chloroquinolines (2a-g) were prepared, of which four were used as precursors (2a-d) and reacted with different anhydrides. Using a clean synthetic approach, 4-alkylamino-7-chloroquinoline-succinimides (3a-d) and -phthalimides (5a-d) were obtained in yields of 60%-99% after only filtration with distilled water. In vitro assays were performed to determine the minimum inhibitory/bactericidal concentration (MIC/MBC) against Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus mutans. Lipophilicity (log P) and toxicity were predicted using the pkCSM program. In vitro toxicity tests on Artemia salina larvae were used as an indicator of ecotoxicity. 4-Alkylamino-7-chloroquinolines (2b, 2f, 2g) revealed a moderate MIC of 156.25 µg·mL

Indexed as

Anti-Bacterial AgentsQuinolinesAnimalsArtemiaBacteriaDose-Response Relationship, DrugEcotoxicologyHydrophobic and Hydrophilic InteractionsMicrobial Sensitivity TestsMolecular StructurePhthalimidesStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsPhthalimidesQuinolinesArtemia salinaenvironmental chemistrylipophilicityphthalimidesuccinimide

Identifiers

PMID42720095
PMCPMC13559871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.