Evidence map›Paper›PMID 42719854›Full record

ArticleACS omega2026

Self-Regulated ROS Nanoplatform Enables Sequential Antibacterial Therapy and Inflammation Resolution in Periodontitis.

Jingdan Zhang, Yue Sun, Wenping Yao, Qiqi Wang, Hao Han, Wenyu Jiao, Yu Huan, Rongkaixuan Fang, Chenghong Cao, Meiya Suo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Porphyrin-Based Porous Materials for Antibacterial Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jingdan ZhangDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun 130021, China.
Yue SunDepartment of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0003-2143-5516
Wenping YaoState Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
Qiqi WangDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0009-0006-1907-5864
Hao HanState Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
Wenyu JiaoState Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
Yu HuanDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun 130021, China.
Rongkaixuan FangJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun 130012, China.
Chenghong CaoDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun 130021, China.
Meiya SuoDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun 130021, China.
Shuya ZhangJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun 130012, China.
Lan ADepartment of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0002-4296-6052
Wenzhou XuDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0003-4646-5340

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection-associated inflammatory diseases such as periodontitis are driven not only by persistent bacterial biofilms but also by dysregulated host immune responses amplified by excessive reactive oxygen species (ROS). Although antimicrobial photodynamic therapy (PDT) efficiently eradicates pathogens, uncontrolled ROS accumulation often aggravates inflammation and impairs tissue repair, limiting its clinical translation. Here, we report a self-regulated ROS nanoplatform based on a one-dimensional porphyrin-diketopyrrolopyrrole covalent organic framework (COF) loaded with the natural flavonoid naringin (COF-Por-DPP@Naringin), which enables temporally programmed ROS generation and scavenging. Under 660 nm irradiation, the COF scaffold induces a transient ROS surge sufficient to eradicate

Identifiers

PMID42719854
PMCPMC13557269

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.