Evidence map›Paper›PMID 42719838›Full record

ArticleInfection and drug resistance2026

Antimicrobial Decision-Making in Culture-Negative Bacterial Meningitis with mNGS-Detected

Yan Li, Yuyuan Hu, Yuhang Yang, Wen Yuan Li, Minghua Fan, Wei Zhang, Yanhong Wang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan Li *Department of Neurology, Shanxi Bethune Hospital (Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan, Shanxi, People's Republic of China.
Yuyuan Hu *Division of Colorectal Surgery, Shanxi Bethune Hospital (Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan, Shanxi, People's Republic of China.
Yuhang Yang *Division of Colorectal Surgery, Shanxi Bethune Hospital (Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan, Shanxi, People's Republic of China.
Wen Yuan Li *Department of Neurology, Shanxi Bethune Hospital (Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan, Shanxi, People's Republic of China.
Minghua FanDepartment of Neurology, Shanxi Bethune Hospital (Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan, Shanxi, People's Republic of China.
Wei ZhangDepartment of General Surgery, Yuncheng Central Hospital Affiliated to Shanxi Medical University, Yuncheng, Shanxi, People's Republic of China.
Yanhong WangDepartment of Neurology, Shanxi Bethune Hospital (Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Taiyuan, Shanxi, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anaerobic meningitis is uncommon and may be underrecognized when cerebrospinal fluid (CSF) culture is non-diagnostic, particularly after antimicrobial exposure or when anaerobic collection, transport, and incubation conditions are suboptimal. Metagenomic next-generation sequencing (mNGS) can provide complementary microbiological evidence in selected culture-negative central nervous system (CNS) infections, but low-biomass CSF results require explicit quality-control reporting and careful assessment of contamination and clinical plausibility. We report two culture-negative bacterial meningitis cases in which CSF mNGS showed a

Indexed as

anaerobic meningitisantimicrobial decision-makingcase reportcentral nervous system infectionculture-negative meningitismetagenomic next-generation sequencingPrevotella oris

Identifiers

PMID42719838
PMCPMC13557220

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.