Evidence map›Paper›PMID 42719763›Full record

Observational studyTransplant international : official journal of the European Society for Organ Transplantation2026

Abdominal normothermic regional perfusion is associated with improved graft survival in liver transplantation from circulatory death donors.

Giulia Magini, Hannah Wozniak, Antonia Schafer, Beat Moeckli, Vanessa Banz, Julien Vionnet, Ansgar Deibel, Jose Oberholzer, Pascale Tinguely, Nicolas Goossens and 9 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Transplant international : official journal of the European Society for Organ Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Giulia MaginiDivision of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland.
Hannah WozniakIntensive Care Division, Geneva University Hospitals, Geneva, Switzerland.
Antonia SchaferTransplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland.
Beat MoeckliDivision of Abdominal Surgery, Geneva University Hospitals, Geneva, Switzerland.
Vanessa BanzDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Julien VionnetTransplantation Center, Service of Gastroenterology and Hepatology and Service of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Ansgar DeibelDepartment of Gastroenterology and Hepatology, University Hospital Zürich, University of Zürich, Zurich, Switzerland.
Jose OberholzerDepartment of Visceral and Transplantation Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Pascale TinguelyDepartment of Visceral and Transplantation Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Nicolas GoossensDepartment of Gastroenterology and Hepatology, Geneva University Hospitals, Geneva, Switzerland.
Andrea PelosoDivision of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland.
Mirjam KornerSwisstransplant, The Swiss National Foundation for Organ Donation and Transplantation, Bern, Switzerland.
Franz ImmerSwisstransplant, The Swiss National Foundation for Organ Donation and Transplantation, Bern, Switzerland.
Riccardo De CarlisDivision of Hepatic Surgery and Liver and Kidney Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Christian TosoDivision of Abdominal Surgery, Geneva University Hospitals, Geneva, Switzerland.
Benjamin AssoulineIntensive Care Division, Geneva University Hospitals, Geneva, Switzerland.
Karim BendjelidIntensive Care Division, Geneva University Hospitals, Geneva, Switzerland.
Philippe CompagnonDivision of Transplantation, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland.
Raphael GiraudIntensive Care Division, Geneva University Hospitals, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced preservation strategies are increasingly used in liver transplantation following donation after circulatory death (DCD). This nationwide observational study evaluated the association between abdominal normothermic regional perfusion (A-NRP) and 1-year graft survival in a Swiss cohort of 254 DCD liver transplants performed between 2017 and 2023. Recovery strategies compared included A-NRP and super-rapid recovery (SRR), both predominantly followed by end-ischemic hypothermic oxygenated perfusion (HOPE). Primary endpoint was 1-year graft loss; secondary endpoints included 1-year patient mortality, primary non-function, non-anastomotic strictures (NAS), biliary and vascular complications and need for re-transplantation. Overall, 53 grafts were retrieved using A-NRP (71% followed by HOPE) and 201 using SRR (90% followed by HOPE). Compared with SRR, A-NRP grafts demonstrated lower rates of graft loss (5.7% vs. 24.6%), 1-year mortality (1.9% vs. 13.3%), NAS (5.7% vs. 20.5%), other biliary complications (1.9% vs. 12.6%) and re-transplantation (3.8% vs. 12.8%). In multivariable Cox regression analysis, A-NRP was associated with lower risk of 1-year graft loss and patient mortality after adjustment for UK DCD risk category and HOPE use. These findings suggest that A-NRP is associated with improved outcomes. Further studies are needed to define the role of

Indexed as

Graft SurvivalLiver TransplantationOrgan PreservationPerfusionAdultFemaleHumansMaleMiddle AgedSwitzerlandTissue Donorsdonation after circulatory death donorend-ischemic hypothermic oxygenated perfusionischemic cholangiopathyliver transplantationnormothermic regional perfusion

Identifiers

PMID42719763
PMCPMC13557021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.