ArticleAnnals of thoracic surgery short reports2026
A Rare Case of Rosai-Dorfman Disease Involving Great Vessels of the Heart Mimicking Breast Cancer Recurrence.
Article in Annals of thoracic surgery short reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rosai-Dorfman disease (RDD) is a rare non-Langerhans histiocytosis, with cardiovascular involvement in <0.1% of cases. We report the case of a 69-year-old woman with history of breast cancer found to have mediastinal nodules involving the superior vena cava and pulmonary veins. Imaging suggested recurrence of malignant disease, and multiple biopsies were nondiagnostic. Definitive diagnosis was achieved after median sternotomy under cardiopulmonary bypass with superior vena cava resection and prosthetic reconstruction. Histopathologic analysis confirmed RDD with abundant IgG4-positive plasma cells. This case illustrates the diagnostic complexity of extranodal RDD and the role of surgery in cardiovascular involvement.
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