Evidence map›Paper›PMID 42719562›Full record

ReviewFrontiers in immunology2026

Immunoregulatory mechanisms in parasitic eosinophilic lung disease: the role of IgE immune complexes and NLRC4 inflammasome.

Yuanchao Cao, Dingyu Rao, Zongbo Peng, Zihao Chen, Qinghui Xia, Chunfa Xie, Yanglin Fu, Defa Huang, Zuxiong Zhang, Chuan Yao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuanchao CaoDepartment of Cardiothoracic Surgery, The Affiliated Hospital of Jiujiang University, Jiujiang, China.
Dingyu RaoDepartment of Thoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Zongbo PengThe First Clinical College, Gannan Medical University, Ganzhou, China.
Zihao ChenThe First Clinical College, Gannan Medical University, Ganzhou, China.
Qinghui XiaThe First Clinical College, Gannan Medical University, Ganzhou, China.
Chunfa XieDepartment of Thoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Yanglin FuThe First Clinical College, Gannan Medical University, Ganzhou, China.
Defa HuangLaboratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Zuxiong ZhangDepartment of Thoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Chuan YaoDepartment of Cardiothoracic Surgery, The Affiliated Hospital of Jiujiang University, Jiujiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parasitic eosinophilic lung disease is characterized by eosinophil infiltration and dysregulated immune responses, posing significant challenges due to its complex immunoregulatory mechanisms which remain incompletely understood. This review explores the emerging role of IgE immune complexes (IgE ICs) in modulating eosinophilic immune responses, proposing a hypothetical signaling axis involving the NLRC4 inflammasome that may influence disease progression. We synthesize preliminary evidence from cellular models and discuss the potential implications of this pathway for parasitic eosinophilic lung disease. Integrating recent findings, we explore how IgE ICs interact with Toll-like receptor 2 (TLR2) and Fc epsilon receptor II (FcϵRII) to regulate eosinophil inflammatory responses, degranulation, and the expression of associated proteins. These interactions reveal a dual regulatory function of immune complexes in parasitic infections and related pulmonary disorders. By critically examining the available evidence for crosstalk between IgE ICs and the NLRC4 inflammasome, this review aims to provide a conceptual framework and hypothesis-generating perspectives for developing targeted immunotherapeutic strategies for parasitic eosinophilic lung disease. Importantly, we acknowledge that the mechanistic evidence for this axis is primarily derived from

Indexed as

Antigen-Antibody ComplexApoptosis Regulatory ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsImmunoglobulin EInflammasomesParasitic DiseasesPulmonary EosinophiliaAnimalsEosinophilsHumansSignal TransductionAntigen-Antibody ComplexApoptosis Regulatory ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsImmunoglobulin EInflammasomesNLRC4 protein, humaneosinophilsFcϵRIIhypothetical immunoregulatory axisIgE immune complexesimmunoregulationinflammatory responseNLRC4 inflammasomeparasitic eosinophilic lung disease

Identifiers

PMID42719562
PMCPMC13555256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.