ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Elecsys pT181p immunoassay: Clinical performance for ruling out amyloid pathology.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionPlasma biomarker rule-out tests can be used early in the Alzheimer's disease (AD) diagnostic pathway to identify people with low likelihood of amyloid pathology.
methodsA care setting-agnostic cutoff for the Elecsys
resultsAt a care setting-agnostic cutoff of 0.934 pg/ml, high negative predictive value (NPV) (93.8%) and acceptable positive predictive value (PPV) (46.6%) were observed against amyloid-positron emission tomography (PET). A primary care-specific cutoff of 0.722 pg/ml showed high NPV (97.9%) against amyloid-PET. Amyloid positivity prevalence for each cutoff population was 22.5% and 13.1%, respectively. DISCUSSION: The pT181p immunoassay is a high-performance test that may substantially help improve access to amyloid pathology testing for people requiring confirmation, potentially leading to timely clinical decisions and better outcomes.
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