Evidence map›Paper›PMID 42719448›Full record

ArticleJournal of vascular anomalies2026

Reproductive considerations in patients undergoing treatment for complex lymphatic anomalies.

Adriana N Vest, Selena U Park, Kiley Hunkler, Luciana Daniela Garlisi Torales, Kwabena Aboagye, Deena Zeltser, Andrea Bowling, Clarisa R Gracia, Alan DeCherney, Sarah E Sheppard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular anomalies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adriana N VestDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Selena U ParkReproductive Endocrinology and Infertility, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Kiley HunklerReproductive Endocrinology and Infertility, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Luciana Daniela Garlisi ToralesUnit on Vascular Malformations, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Kwabena AboagyeUnit on Vascular Malformations, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Deena ZeltserUnit on Vascular Malformations, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Andrea BowlingUnit on Vascular Malformations, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Clarisa R GraciaReproductive Endocrinology and Infertility, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Alan DeCherneyReproductive Endocrinology and Infertility, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Sarah E SheppardUnit on Vascular Malformations, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.

Funding

Cellular and Molecular Mechanisms of Vascular MalformationsZIAHD009003 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SHEPPARD, SARAH · 2022 to 2025
$6.1M
Intramural NIH HHS ZIA HD009003
6 · The paper itself

Abstract

Complex lymphatic anomalies (CLAs) are a spectrum of lymphatic malformations affecting multiple organ systems. These disorders are characterized by a wide variability in presentation features, which often delays accurate diagnosis and complicates characterization and differentiation. Little is known about the gynecologic and reproductive effects of CLAs or their associated treatments, such as long term systemic immunosuppressive medications and repurposed single molecule inhibitors. In this case report, we discuss a patient presenting for gynecologic and fertility preservation consult in the setting of treatment for CLA. The subsequent fertility preservation cycle resulted in a suboptimal yield, illustrating the need for early involvement of reproductive endocrinologists in the care of these patients prior to any potential decline in their ovarian reserve. Further studies are needed to evaluate the effect of disease and medications on reproductive health and female fertility.

Indexed as

Complex lymphatic anomaliesfertilityreproduction

Identifiers

PMID42719448
PMCPMC13557179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.