ArticleCureus2026
Paraplegia Caused by IgG4-Related Hypertrophic Pachymeningitis With an Elevated Cerebrospinal Fluid Immunoglobulin G4 Concentration.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Immunoglobulin G4-related hypertrophic pachymeningitis (IgG4-RP) is a rare manifestation of immunoglobulin G4 (IgG4)-related disease and an uncommon cause of hypertrophic pachymeningitis (HP). Because serum IgG4 concentration is not necessarily elevated, the diagnosis of IgG4-RP is often challenging. We report a rare case of IgG4-RP in a 78-year-old woman presenting with complete paraplegia, sensory loss in the lower extremities, and bladder and rectal dysfunction. Gadolinium-enhanced magnetic resonance imaging showed enhancing spinal epidural lesions. A histopathological examination revealed dense lymphocyte and plasma-cell infiltration with fibrosis and increased IgG4-positive plasma cells, leading to the diagnosis of IgG4-RP. Although the serum IgG4 concentration was within the reference range, retrospective analysis of cerebrospinal fluid (CSF) showed a markedly elevated IgG4 concentration, with an increased IgG4 index and IgG4
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