ArticleDose-response : a publication of International Hormesis Society
Shape-Restricted Detection of Natural Product Hormesis: A Re-Analysis of Complex Botanical Mixtures.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Botanical supplements are consumed to improve health despite the mystery of their mechanisms. One possible effect is hormesis, defined as a beneficial and stimulatory health effect at a low dose and detrimental effect at a high dose, or vice versa. Hormesis is usually discovered by manually examining the shape of dose-response curves, which is not scalable to the large number of chemical-assay combinations found in high-throughput screening (HTS) results. Methods: We proposed a semi-automatic statistical testing procedure to quickly evaluate large-scale dose-response data, accompanied by an R package Results: We applied this method to a data set of 4860 chemical-assay pairs and identified 561 (12%) dose-response curves showing statistically significant hormesis. Conclusion: Our discovery of hormetic curves is in line with estimates of hormetic behaviors in dose-response repositories like Tox21. Our proposed method has been effective in screening for hormesis from large-scale dose-response data, and the visualization method effectively facilitates the interpretation of test results.
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