ArticleClinical Medicine Insights. Cardiology2026
Unveiling the Unknown: A Case Report of Undifferentiated Pleomorphic Sarcoma in the Heart.
Article in Clinical Medicine Insights. Cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Undifferentiated pleomorphic sarcoma (UPS) of the heart is an exceedingly rare and highly aggressive tumor. We present the case of a 66-year-old male with a history of stage I prostatic acinar adenocarcinoma who was incidentally found to have a left atrial mass during cancer workup. Multimodal imaging (echocardiography, CMR, PET-CT) initially suggested a benign lesion. The patient underwent surgical excision of the mass, which revealed UPS confirmed by histopathology and immunohistochemistry. Postoperatively, the patient experienced right-sided heart failure, recurrent skin ulcers requiring grafting, and atrial arrhythmia. Despite complications, he stabilized and started chemotherapy and oncologic follow-up. This case highlights the diagnostic pitfalls of cardiac UPS, the necessity for tissue confirmation, and the role of coordinated multidisciplinary care.
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