ArticleJournal of ginseng research2026
Novel indole alkaloids from the flower buds of
Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: While the chemical constituents of flower buds from several Methods: Flower buds were extracted with methanol, then fractionated by liquid-liquid partitioning and chromatography. Structures of isolated compounds were elucidated using NMR and MS. Their distribution in flower buds and various berry stages was analysed by HPTLC, HPLC/PDA, and UPLC-QToF-MS. Anti-bacterial activity was evaluated Results: Two novel indole alkaloids, panaxindolic acid and pyrindolic acid, with the known alkaloid panaxindole and tryptophan, were isolated. All identified alkaloids were detected in multiple reproductive parts, indicating a broad distribution. Docking simulations predicted strong binding of the isolated alkaloids toward monoamine oxidase B (MAO-B) through hydrogen bonding and π-π stacking with key residues, including CYS172 and TYR398. Although panaxindole exhibited limited anti-bacterial activity Conclusion: This study presents the first systematic investigation of indole alkaloids from PVF flower buds and their distribution across reproductive organs. Although
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