ArticleFrontiers in psychiatry2026
Personality characteristics, alexithymia and anxiety/depression in breast cancer patients undergoing radiotherapy: a cross-sectional mediation analysis.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aims to explore the relationship between personality characteristics and both anxiety and depression in breast cancer patients undergoing radiotherapy after surgery, and to assess the indirect effects of alexithymia. Methods: This cross-sectional study was conducted in the Department of Radiation Oncology from January 2024 to May 2024. A convenient sampling method was used to recruit breast cancer patients receiving radiotherapy after surgery. Participants completed the survey during the last two weeks of their treatment. Personality characteristics were assessed using the Eysenck Personality Questionnaire (EPQ), alexithymia using the Toronto Alexithymia Scale (TAS-26), and anxiety/depression using the Hospital Anxiety and Depression Scale (HADS). Correlation and mediation analyses of anxiety, depression, personality characteristics, and alexithymia were conducted using SPSS version 27.0 with the PROCESS macro. Results: A total of 231 patients were included in the analysis. The rates of probable anxiety and depression among breast cancer patients undergoing radiotherapy after surgery were 34.6% and 51.5%, respectively. Neuroticism and psychoticism were positively correlated with both anxiety and depression (r ranging from 0.246 to 0.571, all Conclusions: This study suggests that personality characteristics are associated with anxiety and depression in breast cancer patients undergoing radiotherapy, with alexithymia showing significant indirect effects in these relationships. Given the cross-sectional design, these findings represent indirect associations rather than causal pathways.
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