ArticleFrontiers in surgery2026
Morphometric and immunohistochemical reorganisation of the palatine tonsil in chronic tonsillitis and its response to combined ozone-ultrasound therapy.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic tonsillitis is a common upper respiratory tract disease for which there is no objective tissue-level basis for judging conservative treatment. We characterised the morphometric and immunohistochemical reorganisation of the palatine tonsil in chronic tonsillitis and its response to a combined ozone-ultrasound protocol. Methods: In a single-centre observational study with a pre-post design and no randomised comparator group, we examined 480 palatine tonsil specimens: histologically normal controls ( Results: Chronic tonsillitis showed deepened crypts (+412.3%), capsular thickening (+252.6%), epithelial erosion (+152.5%) and stromal fibrosis (+54.0%), whereas epithelial thickness changed marginally (+6.6%). Follicle density fell by 54.7% and germinal centre number by 22.1%, while germinal centre area was preserved (-4.3%; Conclusion: Chronic tonsillitis produces a reproducible pattern of morphometric and immunohistochemical reorganisation that responds in a coordinated way to combined ozone-ultrasound therapy, giving an objective tissue-level framework for judging conservative treatment.
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