ArticleFrontiers in psychiatry2026
Analysis of risk factors for attention deficit hyperactivity disorder among children in Hubei region based on liquid chromatography-tandem mass spectrometry.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To quantitatively assess nutritional elements using LC-MS/MS, this study examines the correlations between nutritional elements and vitamins and ADHD in children residing in Hubei Province. Additionally, it explores the associations among various monitoring indicators, thereby providing a reference for the clinical diagnosis and treatment of ADHD. Methods: The study cohort comprised 354 children diagnosed with ADHD and 350 healthy controls, all of whom attended the Child Health Care Department of Hubei Provincial Maternal and Child Health Hospital between January 2023 and December 2025. Nutritional elements were quantified using ICP-MS, while serum levels of vitamins A and D were measured via LC-MS/MS. Comparative analyses were conducted to identify differences between the groups. Univariate and multivariate logistic regression analyses were employed to evaluate the correlations between these nutritional indicators and ADHD, as well as to identify independent associated factors. Results: The serum concentrations of vitamins A and D were found to be notably lower in the ADHD group compared to the control group ( Conclusion: Vitamin A and vitamin D deficiencies are prevalent among children with ADHD in Hubei Province, and low levels of these vitamins are independently associated with an increased likelihood of ADHD.
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