Evidence map›Paper›PMID 42718978›Full record

ArticleFrontiers in immunology2026

p38γ and p38δ support CD4

Diego González-Romero, Ester Díaz-Mora, Pilar Fajardo, Juan José Sanz-Ezquerro, Yolanda R Carrasco, Ana Cuenda

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Diego González-RomeroDepartment of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)/CSIC, Madrid, Spain.
Ester Díaz-MoraDepartment of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)/CSIC, Madrid, Spain.
Pilar FajardoDepartment of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)/CSIC, Madrid, Spain.
Juan José Sanz-EzquerroDepartment of Cellular and Molecular Biology, CNB/CSIC, Madrid, Spain.
Yolanda R CarrascoB Lymphocyte Dynamics, Department of Immunology and Oncology, CNB/CSIC, Madrid, Spain.
Ana CuendaDepartment of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)/CSIC, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

p38γ and p38δ (p38γ/p38δ) have emerged as important regulators of immune function; however, their specific contribution to adaptive humoral responses remains poorly understood. Based on previous evidence that global p38γ/p38δ deficiency impairs antibody production, we investigated the T cell-intrinsic role of these kinases using conditional knockout mouse models. T cell-specific combined deletion of p38γ and p38δ altered antigen-specific IgG subclass production

Indexed as

CD4-Positive T-LymphocytesImmunity, HumoralMitogen-Activated Protein Kinase 12Mitogen-Activated Protein Kinase 13AnimalsCell DifferentiationCytokinesImmunoglobulin GLymphocyte ActivationMiceMice, KnockoutT Follicular Helper CellsCytokinesImmunoglobulin GMitogen-Activated Protein Kinase 12Mitogen-Activated Protein Kinase 13CD4humoral immunityp38γ MAPKp38δ MAPKT follicular helper cells (TFH)

Identifiers

PMID42718978
PMCPMC13553806

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.