ArticleClinical medicine insights. Arthritis and musculoskeletal disorders2026
The Association Between Platelet Indices and Osteoarthritis: A Systematic Review and Meta-analysis.
Article in Clinical medicine insights. Arthritis and musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: The role of routinely available platelet biomarkers - platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) - is poorly understood in osteoarthritis (OA). This systematic review and meta-analysis aimed to assess the association between platelet biomarkers and the occurrence and severity of OA. Methods: MEDLINE, Embase and the Cochrane libraries were searched from inception to June 2025. We included studies reporting on the association between PLT, MPV, PDW and PCT with the presence and severity of OA. We tabulated mean differences (MDs) of platelet biomarkers between patients with OA against healthy controls, as well as between patients with severe OA and mild/moderate OA to generate pooled effect measures using random-effects inverse variance modelling. Results: Fourteen studies, with a total of 13 843 patients, were included in this systematic review. Mean platelet volume (fL) was significantly reduced in OA as compared to healthy controls, MD = -0.52 (95% CI: -0.65 to -0.39, Conclusions: This meta-analysis found MPV to be significantly reduced in OA. Further studies are needed to further evaluate the prognostic significance of mean platelet volume in OA.
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