ReviewJournal of tissue engineering
The dental pulp as a high-resolution model for neurovascular niche biology.
Review in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Building functional tissue in vitro shares a common ceiling. Current models span vascular co-development, trophic interaction, vascular-to-neural sensitization, barrier function, and even functional neuromuscular coupling, yet none has reconstituted functional neurovascular (NV) coupling. We argue that, on one specific axis, the dental pulp is the most direct single-source substrate for dissecting this coupling. A single, clinically accessible neural-crest tissue supplies the perivascular compartment together with glial and neurotrophic support for the neural compartment, in a volume amenable to single-cell methods and one in which an activity-dependent NV interaction is already measurable in vivo. This is a competence claim, not a demonstration; no in-vitro pulp model has closed the loop, leaving unresolved the clinical divergence between reversible and irreversible pulpitis. The review identifies the clinical, experimental, and mechanistic questions a pulp model could resolve, yielding a transferable method for other NV-coupled tissues.
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Registered trials
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