ArticleBrain, behavior, & immunity - health2026
Temporal coupling of cortisol and immune cell responses in acute psychosocial stress.
Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
Acute psychosocial stress triggers coordinated neuroendocrine and immune responses, yet the temporal coupling between cortisol release and leukocyte redistribution in humans remains understudied. In a sample of 302 participants (aged 18 to 59 years; 64 % female) drawn from the Swedish Twin Registry, we characterized trajectories of neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio (NLR) following the Trier Social Stress Test (TSST). Blood samples were collected at five timepoints (pre-stress, and at 5, 30, 60, and 90 min after stress), and plasma cortisol was measured at the first three timepoints. Linear mixed-effects models assessed the effects of time, cortisol response (area under the curve with respect to increase; AUC
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