Evidence map›Paper›PMID 42718926›Full record

SynthesisResearch and practice in thrombosis and haemostasis2026

Efficacy and safety of anticoagulation for pediatric cerebral sinovenous thrombosis: systematic review and meta-analysis.

Muayad Azzam, Hassan Kawtharany, Marisol Betensky, Aseel Alkhader, Qais Hamarsha, Hadi Khaled Abou Zeid, Razan Mansour, Carine Tabak, Payal Patel, Sarah Lamat Baghdadi and 29 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Muayad AzzamEvidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Hassan KawtharanyEvidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Marisol BetenskyDepartment of Pediatrics, Division of Hematology, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
Aseel AlkhaderEvidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Qais HamarshaEvidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Hadi Khaled Abou ZeidDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Razan MansourDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Carine TabakUniversity of Kansas School of Medicine, Kansas City, KS, USA.
Payal PatelDepartment of Emergency Medicine-Critical Care Medicine, Emory University, Atlanta, GA, USA.
Sarah Lamat BaghdadiUniversity of Kansas School of Medicine, Kansas City, KS, USA.
Rachel S BercovitzDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Rukhmi BhatDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Tina BissDepartment of Haematology, The Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, Tyne & Wear, United Kingdom.
Brian R BranchfordDepartment of Hematology, Versiti Medical Sciences Institute, Wauwatosa, WI, USA.
Leonardo R BrandãoDivision of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Anthony K C ChanDepartment of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
E Vincent S FaustinoDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Julie JaffrayDepartment of Pediatrics, Division of Hematology/Oncology, University of California, San Diego, Rady Children's Hospital, San Diego, CA, USA.
Sophie JonesDepartment of Nursing, University of Melbourne, Royal Children's Hospital, Melbourne, Australia.
Bryce A KerlinDepartment of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.
Nicole KucineDepartment of Pediatrics, Weill Cornell Medical College, New York, NY, USA.
Riten KumarDepartment of Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.
Christoph MaleDepartment of Paediatrics, Medical University of Vienna, Vienna, Austria.
Marie-Claude Pelland-MarcotteDivision of Hematology-Oncology, Department of Pediatrics, CHU de Québec, Centre Mère-Enfant Soleil, Québec, QC, Canada.
Leslie RaffiniDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Chittalsinh M RauljiDepartment of Pediatric Hematology Oncology, University of Nebraska Medical Center, Omaha, NE.
Sarah E SartainDepartment of Pediatrics, Section of Hematology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX, USA.
Clifford M TakemotoDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cristina TarangoDepartment of Pediatrics, University of Cincinnati College of Medicine, Cancer and Blood Disease Institute Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
C Heleen Van OmmenDepartment of Pediatric Hematology, Erasmus Medical Center Sophia Children's Hospital, Rotterdam, Netherlands.
Maria C VelezDepartment of Pediatrics, Division of Hematology-Oncology, Louisiana State University Health Sciences Center and Manning Family Children's, New Orleans, LA, USA.
Sara K VeselyHudson College of Public Health, Department of Biostatistics and Epidemiology, University of Oklahoma Health, Oklahoma City, OK, USA.
John WiernikowskiDepartment of Pediatrics, Division of Hematology/Oncology, McMaster University, Hamilton, ON, Canada.
Suzan WilliamsDivision of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Hope P WilsonDepartment of Pediatrics, University of Alabama at Birmingham Heersink School of Medicine and Children's of Alabama, Birmingham, AL, USA.
Gary WoodsDepartment of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Ayesha ZiaDepartment of Pediatrics, Division of Hematology-Oncology, UT Southwestern Medical Center, Dallas, TX, USA.
Paul MonagleDepartments of Paediatrics and Haematology, Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Victoria, Australia.
Reem A MustafaDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed this systematic review and meta-analysis to assess the efficacy and safety of anticoagulation therapy versus no anticoagulation in pediatric patients with cerebral sinovenous thrombosis (CSVT). Eligible studies included pediatric patients with CSVT that compared anticoagulation to no anticoagulation and reported on at least one relevant outcome (mortality, neurological deficit, thrombus resolution, recurrence, and bleeding). Meta-analysis reported risk ratios (RR) or differences (RD) (95% CIs) and absolute effects per 1000 patients. Risk of bias was assessed using ROBINS-I, and the certainty of evidence was evaluated with GRADE. After removing duplicates, we screened 8925 records independently and in duplicate, from which 12 nonrandomized studies of intervention were included. Compared with no anticoagulation, anticoagulation may be associated with lower risk of overall mortality RR 0.14 (0.05-0.39) (4 studies,

Indexed as

AnticoagulantsSinus Thrombosis, IntracranialChildChild, PreschoolHemorrhageHumansOdds RatioRecurrenceRisk FactorsTreatment OutcomeAnticoagulantsanticoagulantscerebral sinovenous thrombosispediatricssystematic review and meta-analysisvenous thromboembolism

Identifiers

PMID42718926
PMCPMC13553567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.