ArticleMultiple sclerosis journal - experimental, translational and clinical
Early switching to ofatumumab avoids a rebound effect after natalizumab cessation in multiple sclerosis patients.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Background: A risk of disease reactivation has been clearly identified after natalizumab cessation in patients with multiple sclerosis (MS). Several studies have demonstrated a low risk of reactivation or rebound in patients switching to anti-CD20, but limited data are available concerning ofatumumab. Objective: In the present study, we evaluated a cohort of 61 MS patients who switched from natalizumab to ofatumumab. Results: After a mean follow-up of 2.4 years (range: 6 months to 4 years), none of the patients had experienced any clinical relapse or magnetic resonance imaging reactivation. Conclusion: We confirm that ofatumumab is likely an effective option, using a short washout period following natalizumab discontinuation.
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