ArticleJournal of ginseng research2026
Ginsenoside Rb1 mitigates radiation-induced intestinal injury through Treg expansion and IL-10-mediated epithelial regeneration.
Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Radiation-induced enteropathy represents a key limitation to recovery after accidental radiation exposure or radiotherapy, with few effective pharmacological treatments. We investigated the therapeutic potential of ginsenoside Rb1, a major saponin from Methods: C57BL/6 mice were exposed to abdominal irradiation at a dose of 13.5 Gy and treated with Rb1. The epithelial integrity, bacterial translocation, and immune modulation were assessed. Results: Rb1 significantly alleviated radiation-induced crypt damage, villus shortening, bacterial translocation, and inflammation. It enhanced regulatory T (Treg) cell population and IL-10 secretion, which in turn activated Wnt/β-catenin signaling and promoted epithelial regeneration. Conclusion: Rb1 mitigated radiation-induced enteropathy by upregulating Treg abundance and IL-10 signaling, which in turn activated epithelial regeneration with Wnt/β-catenin pathway activation, supporting its potential as a therapeutic agent for radiation-induced intestinal injury.
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