ArticleFrontiers in medicine2026
Baseline immune-organ
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
9 authors.
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Abstract
Objective: To investigate whether baseline Methods: We retrospectively analyzed 120 stage III-IV NSCLC patients who underwent Results: irAEs occurred in 66 patients (55.0%) after a median of 61.5 days; 18 (27.3%) had grade 3-4 events, mainly pneumonitis and hepatitis. Compared with non-irAE patients, irAE patients showed higher SLR, spleen SUVmax, bone-marrow indices, thyroid SUVmax, and neutrophil-to-lymphocyte ratio (NLR). In the final multivariable model, SLR (odds ratio [OR] 4.13 per 1-SD; 95% CI, 2.28-7.49; Conclusion: Baseline splenic and thyroid FDG metabolism, combined with systemic inflammation, were independently associated with irAEs in anti-PD-1-treated NSCLC, providing candidate pretreatment risk-stratification markers pending external validation.
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