Evidence map›Paper›PMID 42718796›Full record

ArticleFrontiers in medicine2026

Real-time LC-OCT monitoring of scalp hypertrophic actinic keratosis clearance following cryotherapy, laser, and 5-fluorouracil therapy.

Giulio Bortone, Vincenzo Coppolelli, Luca Gargano, Francesca Svara, Mehdi Boostani, Steven Paul Nisticò, Giovanni Pellacani, Carmen Cantisani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giulio BortoneUOC of Dermatology, Department of Medical and Cardiovascular Science, La Sapienza Medical School of Rome, Rome, Italy.
Vincenzo CoppolelliUOC of Dermatology, Department of Medical and Cardiovascular Science, La Sapienza Medical School of Rome, Rome, Italy.
Luca GarganoUOC of Dermatology, Department of Medical and Cardiovascular Science, La Sapienza Medical School of Rome, Rome, Italy.
Francesca SvaraUOC of Dermatology, Department of Medical and Cardiovascular Science, La Sapienza Medical School of Rome, Rome, Italy.
Mehdi BoostaniDepartment of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Steven Paul NisticòUOC of Dermatology, Department of Medical and Cardiovascular Science, La Sapienza Medical School of Rome, Rome, Italy.
Giovanni PellacaniUOC of Dermatology, Department of Medical and Cardiovascular Science, La Sapienza Medical School of Rome, Rome, Italy.
Carmen CantisaniUOC of Dermatology, Department of Medical and Cardiovascular Science, La Sapienza Medical School of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Assessment of treatment response in hypertrophic actinic keratoses (hAKs) remains largely dependent on clinical examination and dermoscopy, although apparent clearance may not reflect complete resolution of imaging features associated with residual disease. Line-field confocal optical coherence tomography (LC-OCT) enables non-invasive, longitudinal visualization of epidermal, dermal-epidermal junction, and superficial dermal changes at near-cellular resolution. Objective: To characterize LC-OCT response patterns in scalp hAKs treated with ablative CO Methods: This retrospective study included 150 scalp hAKs classified at baseline as KIN 2-3 and PRO II-III, allocated to CO Results: Cryotherapy produced early sub-epidermal blistering, followed by partial imaging response requiring repeated sessions in 40% of lesions. CO Conclusion: LC-OCT enables non-invasive monitoring of treatment-related hAKs modifications and may identify persistent imaging abnormalities despite apparent clinical resolution, supporting individualized sequential treatment strategies.

Indexed as

5-fluorouracilbiological responseCO2 lasercryotherapyDEJ undulation indexfield cancerizationhypertrophic actinic keratosisLC-OCT

Identifiers

PMID42718796
PMCPMC13553471

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.