Splenic transcriptomic profiling reveals innate immune responses and RIG-I-like receptor signaling in goslings infected with goose astrovirus.

Guangzhong Peng, Xinran Guo, Yingjie Gu, Suyu Fan, Xuming Hu, Yang Zhang, Guohong Chen, Wenming Zhao, Qi Xu

Abstract read

In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Guangzhong Peng *Jiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Xinran Guo *Jiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Yingjie GuJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Suyu FanJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Xuming HuJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Yang ZhangJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Guohong ChenJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Wenming ZhaoJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Qi XuJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Goose astrovirus (GAstV) is an important pathogen associated with visceral gout, growth retardation, and mortality in goslings, whereas the splenic response to infection remains poorly understood. In this study, GAstV-infected goslings showed positive viral RNA detection in spleen tissues, obvious splenomegaly, and histopathological lesions. Transcriptomic analysis identified 383 differentially expressed genes, including 243 upregulated and 140 downregulated genes. Functional enrichment analyses showed that these genes were mainly involved in antiviral defense, innate immune responses, complement and coagulation cascades, and the RIG-I-like receptor signaling pathway. GSEA further supported the enrichment of the RIG-I-like receptor signaling pathway in infected spleens. Notably, several genes related to this pathway, including

Indexed as

goose astrovirusinnate immunityRIG-I-like receptor signaling pathwayspleentranscriptome

Identifiers

PMID42718786

DOI10.3389/fvets.2026.1911277

PMCPMC13553421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.