Evidence map›Paper›PMID 42718692›Full record

ArticleFrontiers in nephrology2026

Assessment of patient perspectives in the CONVINCE trial in end-stage kidney disease - a domain-guided approach.

Kathrin I Fischer, Krister Cromm, Peter J Blankestijn, Bernard Canaud, Jörgen Hegbrant, Claudia Barth, Mark Woodward, Giovanni F M Strippoli, Andrew Davenport, Michiel L Bots and 1 more

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In one paragraph

Article in Frontiers in nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kathrin I FischerCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik mit Schwerpunkt für Psychosomatik, Center for Patient-Centered Outcomes Research, Berlin, Germany.
Krister CrommCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik mit Schwerpunkt für Psychosomatik, Center for Patient-Centered Outcomes Research, Berlin, Germany.
Peter J BlankestijnDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, Netherlands.
Bernard CanaudSchool of Medicine, Montpellier University, Montpellier, France.
Jörgen HegbrantDivision of Nephrology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Claudia BarthB. Braun Avitum AG, Medical Scientific Affairs, Melsungen, Germany.
Mark WoodwardThe George Institute for Global Health, Imperial Collage London, London, United Kingdom.
Giovanni F M StrippoliDepartment of Precision and Regenerative Medicine and Ionian Area (DIMEPRE-J), University of Bari, Bari, Italy.
Andrew DavenportUniversity College London (UCL) Department of Renal Medicine, Royal Free Hospital, Division of Medicine, University College London, London, United Kingdom.
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Matthias RoseCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik mit Schwerpunkt für Psychosomatik, Center for Patient-Centered Outcomes Research, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patient-reported outcome (PRO) measures are increasingly used in clinical trials and clinical care to assess symptoms, functioning, and health-related quality of life (HRQoL). In dialysis research, instrument-driven approaches that rely on legacy measures may not fully capture outcomes that matter most to patients or treatment-related experiences such as dialysis-specific fatigue and recovery. Therefore, a patient-informed, domain-guided PRO toolbox for adults with end-stage kidney disease (ESKD) receiving maintenance dialysis was developed and applied in the CONVINCE trial. Methods: A multi-method, triangulation approach was used, comprising: 1) a targeted literature review of PROMs and symptom concepts used in maintenance dialysis research, 2) review of international core outcome initiatives relevant to kidney disease and haemodialysis, 3) semi-structured interviews and focus groups with patients ( Results: The literature review identified 97 PROMs. Domains and symptom content were extracted from these instruments and mapped against concepts covered by international core outcome initiatives and qualitative data. Triangulation resulted in an ESKD PRO toolbox comprising nine prioritized health domains: general health/health perception, fatigue, physical function, social roles, depression, anxiety, pain, sleep, and cognitive function. Most of these domains could be assessed within the PROMIS Conclusion: The ESKD PRO toolbox provides a patient-informed, domain-guided framework for repeated longitudinal assessment of outcomes relevant to patients receiving maintenance dialysis. Its application in CONVINCE illustrates how PROMIS

Indexed as

end-stage kidney diseasemaintenance dialysis therapypatient perspectivepatient-reported outcome measuresqualitative researchquality of life

Identifiers

PMID42718692
PMCPMC13553382

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.