Evidence map›Paper›PMID 42718690›Full record

ArticleFrontiers in oncology2026

MiR-150-5p suppresses high-grade transformation of lacrimal adenoid cystic carcinoma by downregulating COL1A1.

Xiaoyu Zhu, Jinjie Liu, Meixia Jiang, Xun Liu, Shuang Chen, Tingting Lin, Limin Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoyu Zhu *Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Jinjie Liu *Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Meixia Jiang *Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China.
Xun LiuTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Shuang ChenTianjin Key Laboratory of Early Drug Evaluation of Innovative Drugs, Tianjin International Joint Academy of Biomedicine, Tianjin, China.
Tingting LinTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Limin ZhuTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lacrimal adenoid cystic carcinoma (LACC) is the most common malignant epithelial tumor of the lacrimal gland, with particularly high recurrence and mortality in cases with high-grade transformation (HGT-LACC). This study aims to investigate the functional role of miR-150-5p in regulating the HGT of LACC. MiRNA microarray and proteomic mass spectrometry were performed on paired LACC and HGT-LACC tissues to identify differentially expressed miR-150-5p and its potential target COL1A1. The miR-150-5p/COL1A1 interaction was validated by luciferase reporter assay, and the effects of miR-150-5p on proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) were assessed

Indexed as

COL1A1epithelial-mesenchymal transitionhigh-grade transformationlacrimal gland adenoid cystic carcinoma (LACC)miR-150-5p

Identifiers

PMID42718690
PMCPMC13553393

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.