ArticleNature. Mental health2026
Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.
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Article in Nature. Mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
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Who cites it
13 citing papers in PubMed.
- Age at Autism Diagnosis in the Norwegian Mother, Father, and Child Cohort Study (MoBa): Exploring the Association With Family Well-Being.Autism : the international journal of research and practice · 2026Article
- Eating Disorders and Parkinson's Disease-2: Genetic Epidemiology and Shared Genomics.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- Investigating Relationships Between Genetic Risk, Childhood Maltreatment, and Eating Disorders in Women.Biological psychiatry global open science · 2026Article
- Dynamic neuro-immune regulation of psychiatric risk loci in human neurons.Nature communications · 2026Article
- Article
- Weight gain and brain development in the ABCD study cohort: A decade of insight and the road ahead.Developmental cognitive neuroscience · 2026Review
- Clinical staging for eating disorders: A scoping review and update.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Anchoring Anorexia Nervosa Within Biological Psychiatry Through Metabolic Pathways.Biological psychiatry global open science · 2026Article
- Eating and Mental Health Disorders.Nutrients · 2026Article
- Childhood Mental Health and Body Mass Index as Mediators of Genetic Risk for Eating Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Shared genetic architecture between anorexia nervosa and metabolomic biomarkers suggest underlying causal pathways.medRxiv : the preprint server for health sciences · 2025Article
- Within-Person Changes in Daily Ovarian Hormone Levels Influence Genetic Effects on Emotional Eating in Women.The International journal of eating disorders · 2025Article
- Gondal hormones and binge eating in females: developmental and etiologic insights from puberty to adulthood.Current opinion in psychiatry · 2025Review
Corrections and comments
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Authors and funding
182 authors.
Jet D Termorshuizen *Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Helena L Davies *Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Sang-Hyuck Lee *Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID 0000-0002-5610-033X
Jessica K DennisDepartment of Medical Genetics, University of British Columbia, Vancouver, British Columbia Canada.
Christopher HübelInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Jessica S JohnsonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
Yi LuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9933-3654
Melissa A Munn-ChernoffDepartment of Community, Family and Addiction Sciences, Texas Tech University, Lubbock, TX USA.
Triinu PetersSection of Molecular Genetics in Mental Disorders, LVR University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Baiyu QiDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
Katherine E SchaumbergDepartment of Psychiatry, University of Wisconsin, Madison, WI USA.
Rebecca H SignerDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY USA.
Karanvir SinghGraduate Program in Bioinformatics, University of British Columbia, Vancouver, British Columbia Canada.
Abigail R Ter KuileInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID 0000-0002-7869-3754
Laura M ThorntonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
Jiayi XuDepartment of Psychiatry, Yale University, New Haven, CT USA.ORCID 0000-0001-6379-386X
Shuyang YaoDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9669-4470
Zeynep YilmazNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Ruyue ZhangDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Johan ZvrskovecInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID 0000-0002-8862-0874
Mohamed AbdulkadirNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Ziada AyorechDepartment of Psychology, PROMENTA Research Centre, University of Oslo, Oslo, Norway.
Elizabeth C CorfieldPsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-0119-157X
Alexandra HavdahlDepartment of Psychology, PROMENTA Research Centre, University of Oslo, Oslo, Norway.ORCID 0000-0002-9268-0423
Kristi KrebsEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0003-0494-2751
Taralynn M MackVanderbilt Genetics Institute, Vanderbilt University, Nashville, TN USA.
Maria NiarchouThe Weindrich Department of AI and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY USA.ORCID 0000-0002-8855-7393
Teemu PalviainenInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-7847-8384
Julia M SealockAnalytic and Translational Genetics Unit, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Massachusetts General Hospital, Boston, MA USA.
Jessica H BakerIndependent Researcher, Mebane, NC USA.
Andrew W BergenOregon Research Institute, Springfield, OR USA.
Andreas BirgegårdDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1220-9680
Vesna Boraska PericaDepartment for Medical Biology, University of Split School of Medicine, Split, Croatia.
Katharina BührenDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany.
Roland BurghardtDepartment of Child and Adolescent Psychiatry, Oberberg Fachklinik Fasanenkiez Berlin, Berlin, Germany.
Matteo CassinaDepartment of Women's and Children's Health, University of Padova, Padova, Italy.
Giovanni CastelliniDepartment of Health Sciences, University of Florence, Florence, Italy.
Enrico CollantoniDepartment of Neuroscience, University of Padova, Padova, Italy.ORCID 0000-0002-6730-1778
James J CrowleyDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.ORCID 0000-0001-9051-1557
Unna N DannerAltrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, Utrecht, the Netherlands.
Franziska DegenhardtDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LVR University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Janiece E DeSocioCollege of Nursing, Seattle University, Seattle, WA USA.
Christian DinaNantes Université, CNRS, INSERM, L'Institut du Thorax, Nantes, France.ORCID 0000-0002-7722-7348
Monika Dmitrzak-WęglarzDepartment of Psychiatric Genetics, Medical Biology Center, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0002-0493-8325
Laramie E DuncanDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA USA.ORCID 0000-0003-1131-661X
Karin M EgbertsDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Wuerzburg, Würzburg, Germany.ORCID 0000-0002-0270-0954
Lenka ForetovaCenter of Medical Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.ORCID 0000-0003-0494-2620
Ina GieglingDepartment of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.
Fragiskos GonidakisFirst Department of Psychiatry, National and Kappodistrian University of Athens, Athens, Greece.
Scott D GordonDepartment of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland Australia.ORCID 0000-0001-7623-328X
Jakob GroveDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-2284-5744
Sébastien GuillaumeDepartment of Emergency and Post-Emergency Psychiatry, CHU, University of Montpellier, Montpellier, France.
Jerry D GuintivanoDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
Annette M HartmannDepartment of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.
Konstantinos HatzikotoulasHelmholtz Zentrum München - German Research Centre for Environmental Health, Institute of Translational Genomics, Neuherberg, Germany.
Stefan HermsHuman Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
Hartmut ImgartEating Disorders Unit, Parkland-Klinik, Bad Wildungen, Germany.
Susana Jiménez-MurciaDepartment of Clinical Psychology, University Hospital Bellvitge, Hospitalet del Llobregat, Barcelona, Spain.
Antonio JuliàRheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.ORCID 0000-0001-6064-3620
Gursharan KalsiInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Deborah KaminskáDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Leila J KarhunenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-5801-8041
Hannah L KennedyDepartment of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Kirsty M KiezebrinkInstitute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Theresa KolbDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Janne T LarsenNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Dong LiCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA USA.ORCID 0000-0002-2265-6727
Lisa LilenfeldCollege of Clinical Psychology , The Chicago School, Washington, DC USA.
Mario MajDepartment of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Morten MattingsdalDepartment of Medical Research, Vestre Viken Hospital Trust, Bærum Hospital, Gjettum, Norway.
Paolo MeneguzzoDepartment of Neuroscience, University of Padova, Padova, Italy.ORCID 0000-0003-3323-6071
Allison L MillerDepartment of Pathology and Molecular Medicine, University of Otago, Christchurch, New Zealand.ORCID 0000-0003-3816-2251
Karen S MitchellNational Center for PTSD, VA Boston Healthcare System, Boston, MA USA.
Alessio Maria MonteleoneDepartment of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Catherine M OlsenDepartment of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland Australia.ORCID 0000-0003-4483-1888
Leonid PadyukovDepartment of Medicine Solna, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-2950-5670
Richard ParkerDepartment of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland Australia.ORCID 0000-0003-1451-5622
Michaela A PettieDepartment of Pathology and Molecular Medicine, University of Otago, Christchurch, New Zealand.ORCID 0000-0001-5466-8848
Dalila PintoDepartment of Psychiatry, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY USA.ORCID 0000-0002-8769-0846
Anu RaevuoriDepartment of Psychiatry, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-7704-9441
Samuli RipattiInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0504-1202
Marion E RobertsDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-6824-4413
Paolo SantonastasoDepartment of Neuroscience, University of Padova, Padova, Italy.
Androula SavvaDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ulrike H SchmidtNational Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Trust, London, UK.
Alexandra SchosserFaculty of Medicine, Sigmund Freud University, Vienna, Austria.
Jochen SeitzCenter for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0002-0110-7980
Lenka Ls SlachtovaInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Agnieszka SlopienDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Sandro SorbiDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
Peter S StraubThe Weindrich Department of AI and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY USA.
Jin P SzatkiewiczDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.ORCID 0000-0002-4898-7401
Friederike I TamDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0001-8333-867X
Elena TenconiDepartment of Neuroscience, University of Padova, Padova, Italy.
Alfonso TortorellaDepartment of Psychiatry, University of Perugia, Perugia, Italy.ORCID 0000-0002-8095-2305
Artemis TsitsikaAdolescent Health Unit, Second Department of Pediatrics, 'P. & A. Kyriakou' Children's Hospital, National and Kappodistrian University of Athens, Athens, Greece.
Annemarie A van ElburgAltrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, Utrecht, the Netherlands.
Gudrun WagnerEating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
Hunna J WatsonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.ORCID 0000-0001-8405-381X
Roger Ah AdanAltrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, Utrecht, the Netherlands.ORCID 0000-0001-8994-0661
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1688-6697
Ole A AndreassenDivision of Mental Health and Addiction, NORMENT KG Jebsen Centre, Oslo University Hospital, Oslo, Norway.
Helga AskDepartment of Psychology, PROMENTA Research Centre, University of Oslo, Oslo, Norway.ORCID 0000-0003-0149-5319
Anders D BørglumDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-8627-7219
Harry A BrandtEating Recovery Center, Hunt Valley, MD USA.
David CollierInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Steven CrawfordDepartment of Psychiatry, ERC Pathlight, University of Maryland, St. Joseph Medical Center, Baltimore, MD USA.
Scott CrowDepartment of Psychiatry, University of Minnesota, Minneapolis, MN USA.
Lea K DavisDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY USA.ORCID 0000-0001-5143-2282
Martina de ZwaanDepartment of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-7918-6957
George DedoussisDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Danielle M DickDepartment of Psychiatry, Rutgers University, Piscataway, NJ USA.ORCID 0000-0002-1636-893X
Stefan EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Xavier EstivillResearch Department, Quantitative Genomics Laboratories (qGenomics), Barcelona, Spain.
Angela FavaroDepartment of Neuroscience, University of Padova, Padova, Italy.ORCID 0000-0002-6540-5194
Fernando Fernández-ArandaDepartment of Clinical Psychology, University Hospital Bellvitge, Hospitalet del Llobregat, Barcelona, Spain.ORCID 0000-0002-2968-9898
Krista FischerEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-3521-0599
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Philip GorwoodUniversité Paris Cité, INSERM U1266 (IPNP), Institute of Psychiatry and Neuroscience of Paris, Paris, France.ORCID 0000-0003-1845-3676
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA USA.ORCID 0000-0003-2814-7461
Johannes HebebrandDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LVR University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Beate Herpertz-DahlmannDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Anke HinneySection of Molecular Genetics in Mental Disorders, LVR University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0001-5659-0706
James I HudsonBiological Psychiatry Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA USA.
Craig JohnsonEating Recovery Center, Denver, CO USA.
Jennifer JordanDepartment of Psychological Medicine, University of Otago, Christchurch, New Zealand.ORCID 0000-0003-4699-6301
Allan S KaplanDepartment of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario Canada.
Jaakko KaprioInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455
Andreas Fk KarwautzDepartment of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-9053-998X
Martien Jh KasDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID 0000-0002-4471-8618
Walter H KayeDepartment of Psychiatry, University of California, San Diego, San Diego, CA USA.ORCID 0000-0002-4478-4906
James L KennedyDepartment of Psychiatry, University of Toronto, Toronto, Ontario Canada.ORCID 0000-0002-8733-3806
Martin A KennedyDepartment of Pathology and Molecular Medicine, University of Otago, Christchurch, New Zealand.ORCID 0000-0002-6445-8526
Anna Keski-RahkonenDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Youl-Ri KimDepartment of Psychiatry, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea.
Kelly L KlumpDepartment of Psychology, Michigan State University, East Lansing, MI USA.ORCID 0000-0003-1790-9264
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-4496-6451
Stéphanie Le HellardDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Kelli LehtoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0003-2735-7643
Qingqin S LiDepartment of Neuroscience, Janssen Research and Development LLC, Titusville, NJ USA.
Jolanta LissowskaMaria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.ORCID 0000-0003-2695-5799
Jurjen J LuykxDepartment of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID 0000-0002-6439-2774
Sarah L MaguireInsideOut Institute, University of Sydney, Sydney, New South Wales Australia.ORCID 0000-0003-0754-9189
Nicholas G MartinDepartment of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland Australia.ORCID 0000-0003-4069-8020
Manuel MattheisenDepartment of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia Canada.
Sarah E MedlandDepartment of Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, Queensland Australia.
Philip MehlerEating Recovery Center, Denver, CO USA.
Nadia MicaliCenter for Eating and Feeding Disorders Research, Mental Health Center Ballerup, Copenhagen University Hospital - Mental Health Services, Copenhagen, Denmark.
James E MitchellDepartment of Psychiatry and Behavioral Science, University of North Dakota, Fargo, ND USA.
Palmiero MonteleoneDepartment of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy.
Preben Bo MortensenNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.ORCID 0000-0001-9338-9040
Roel A OphoffCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA USA.ORCID 0000-0002-8287-6457
Hana PapezovaDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Liselotte V PetersenNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Luisa S RajcsanyiSection of Molecular Genetics in Mental Disorders, LVR University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Nicolas RamozUniversité Paris Cité, Paris, France.ORCID 0000-0002-8070-9938
Ted Reichborn-KjennerudPsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0003-4653-0034
Valdo RiccaDepartment of Health Sciences, University of Florence, Florence, Italy.
Stephan RipkeStanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA USA.ORCID 0000-0003-3622-835X
Dan RujescuDepartment of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1432-313X
Filip RybakowskiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Stephen W SchererThe Centre for Applied Genomics, Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario Canada.ORCID 0000-0002-8326-1999
Margarita Ct Slof-Op 't LandtGGZ Rivierduinen Eating Disorders Ursula, Leiden, the Netherlands.
Howard SteigerPsychiatry Department, McGill University, Montreal, Quebec Canada.
Patrick F SullivanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6619-873X
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Eric F van FurthGGZ Rivierduinen Eating Disorders Ursula, Leiden, the Netherlands.
Tracey D WadeDiscipline of Psychology, Flinders Institute for Mental Health and Wellbeing, Adelaide, South Australia Australia.ORCID 0000-0003-4402-770X
Thomas WergeInstitute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.ORCID 0000-0003-1829-0766
David C WhitemanDepartment of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland Australia.
D Blake WoodsideDepartment of Psychiatry, University of Toronto, Toronto, Ontario Canada.
Ya-Ke WuDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.ORCID 0000-0001-8990-3449
Stephan ZipfelDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, Tübingen, Germany.ORCID 0000-0003-1659-4440
Disorders Working Group of the Psychiatric Genomics Consortium
Estonian Biobank (EstBB)
Cynthia M BulikDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7772-3264
Laura M HuckinsDepartment of Psychiatry, Yale University, New Haven, CT USA.ORCID 0000-0002-5369-6502
Gerome BreenInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID 0000-0003-2053-1792
Jonathan R I ColemanInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID 0000-0002-6759-0944
Disorders Working Group of the Psychiatric Genomics Consortium
Funding
Eating Disorders Genetics Initiative (EDGI)R01MH120170 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2019 to 2023
$7.2M1/3 Eating Disorders Genetics Initiative 2 (EDGI2)R01MH136149 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CYNTHIA M BULIK, Laura Marianne Huckins · 2024 to 2026
$5.1MModeling the interaction of physiological and environmental stressors on common variants to psychiatric traitsR01ES033630 · NIEHS · YALE UNIVERSITY · PI Kristen Jennifer Brennand · 2022 to 2026
$4.6MNJ Methadone Maintenance Subject Recruitment for Genomic Analyses and Repository ExpansionR01DA044014 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI JOHNSON, ERIC OTTO · 2017 to 2021
$4.2MThe Epidemiology of the Weiss Cohort ProjectR01DA050495 · NIDA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI WEISS, STANLEY H · 2020 to 2025
$3.8MPredicting the multi-omic impact of psychiatric GWAS associationsR01MH118278 · NIMH · YALE UNIVERSITY · PI HUCKINS, LAURA MARIANNE · 2019 to 2023
$3.6M1/7 PGC: Advancing Discovery and ImpactR01MH124871 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, SULLIVAN, PATRICK F · 2021 to 2025
$3.5MPsycheMERGE: Leveraging electronic health records and genomics for mental health researchR01MH118233 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DAVIS, LEA K, SMOLLER, JORDAN W · 2019 to 2022
$3.1MPredicting Binge and Purge Episodes from Passive and Active Apple Watch Data Using a Dynamical Systems ApproachR01MH119084 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, BUTNER, JONATHAN · 2019 to 2022
$2.8MEmpirical eating disorder classification and validation using prospective studiesR01MH087786 · NIMH · BROWN UNIVERSITY · PI FIELD, ALISON E · 2010 to 2014
$2.5M3/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124839 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANDREASSEN, OLE A, HUCKINS, LAURA MARIANNE · 2021 to 2025
$2.0MIntegrating developmental and genomic approaches to identify early trajectories of eating and internalizing disorder symptomsR01MH134039 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nadia Micali, Jin Peng Szatkiewicz · 2024 to 2026
$1.6MNICHD NIH HHS R01 HD047186NIDA NIH HHS R01 DA044014NIDA NIH HHS R01 DA050495NIEHS NIH HHS R01 ES033630NIMH NIH HHS K01 MH116413NIMH NIH HHS K01 MH123914NIMH NIH HHS R01 MH087786NIMH NIH HHS R01 MH118233NIMH NIH HHS R01 MH118278NIMH NIH HHS R01 MH119084NIMH NIH HHS R01 MH120170NIMH NIH HHS R01 MH124839NIMH NIH HHS R01 MH124871NIMH NIH HHS R01 MH134039NIMH NIH HHS R01 MH136149NIMH NIH HHS R56 MH129437Wellcome Trust
Abstract
Eating disorders-including anorexia nervosa (AN), bulimia nervosa and binge-eating disorder-are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. Here we conducted a genomic meta-analysis of case-control studies of binge-eating behavior (BE; 39,279 cases, 1,227,436 controls), alongside analyses of AN (24,223 cases, 1,243,971 controls) and its subtypes (all European ancestries). We identified six BE-associated loci, including loci associated with a higher body mass index and impulse-control behaviors. AN genome-wide association studies yielded eight loci, validating six loci. Subsequent polygenic risk score analysis demonstrated an association with AN in two East Asian ancestry studies. BE and AN exhibited similar positive genetic correlations with psychiatric disorders but opposing genetic correlations with anthropometric traits. Most of the genetic signal in BE and AN was not shared with body mass index. We have extended eating disorder genomics beyond AN; future work will incorporate multiple diagnoses and global ancestries.
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Behavioural geneticsGenome-wide association studiesGenomicsPsychiatric disorders
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.