Evidence map›Paper›PMID 42718669›Full record

ArticleFrontiers in immunology2026

Cathepsin L potentiates autoimmunity by inhibiting lysosome-mediated STING degradation.

Jia-Qing Xing, Zhi-Hao Zhang, Zeng-Lin Guo, Hong Cai, Qiu-Ying Han, Jie Pan, Min-Yi Feng, Wen Xue, Ming Zhao, Kai Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jia-Qing Xing *Nanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Zhi-Hao Zhang *Nanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Zeng-Lin GuoNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Hong CaiNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Qiu-Ying HanNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Jie PanNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Min-Yi FengNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Wen XueNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Ming ZhaoNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Kai WangNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Xin XuNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Tao LiNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Tian XiaNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.
Li-Ming SunNanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stimulator of interferon genes (STING) orchestrates type I interferon (IFN) production in response to cytosolic DNA and plays essential roles in antiviral defense and autoimmune pathogenesis. The stability of STING determines the activation intensity of the pathway. Therefore, identifying proteins that govern its homeostatic regulation is needed. Here, we uncover the lysosomal protease cathepsin L (CTSL) as a critical stabilizer of STING in cells. CTSL deficiency selectively impairs STING-induced IFN responses without compromising overall lysosomal digestive function. Mechanistically, CTSL interacts with AP1B1 to prevent AP1B1-mediated lysosomal degradation of STING, thereby enhancing IFN signaling. Furthermore,

Indexed as

AutoimmunityCathepsin LLupus Erythematosus, SystemicLysosomesMembrane ProteinsAnimalscGAS-STING Signaling PathwayHumansImmunity, InnateInterferon Type IMiceProteolysisSignal TransductionSTING ProteinCathepsin LCTSL protein, humanInterferon Type IMembrane ProteinsSTING1 protein, humanSting1 protein, mouseSTING ProteinAP1B1cathepsin LSTING homeostasissystemic lupus erythematosustype I interferon

Identifiers

PMID42718669
PMCPMC13553787

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.