ArticleInternational journal of women's health2026
Predictive Value of the Triglyceride-Glucose-Frailty Index for Depression and Cognitive Function in Perimenopausal Women: Insights from CHARLS.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Perimenopause represents a critical neuroendocrine transition stage in the lives of women, characterized by metabolic disorders and physiological vulnerability, which also commonly manifests as depression and cognitive impairment. This study explores associations between the triglyceride-glucose-frailty index (TyGFI) and depression/cognitive impairment in perimenopausal women. Methods: Data were obtained from the 2015 China Health and Retirement Longitudinal Study (CHARLS) and 2,596 perimenopausal women were included. Logistic regression models were used to evaluate the association between TyGFI and depression/cognitive impairment. Restricted cubic spline (RCS) curves were plotted to visualize the dose-response relationship. Subgroup analyses and receiver operating characteristic (ROC) curves were used to assess interaction effects and evaluate the discriminatory ability of TyGFI. The results were expressed as odds ratios (OR) with 95% confidence intervals (CI). Results: Perimenopausal women with higher TyGFI levels exhibited a greater tendency towards depression and cognitive impairment, older age, higher blood pressure, and poorer self-reported health. In the fully adjusted model, each one-point increase in TyGFI was associated with elevated risk of depression (OR = 3.70, 95% CI: 3.18-4.32) and cognitive impairment (OR = 1.51, 95% CI: 1.34-1.71). RCS curves confirmed non-linear, positive associations and clear dose-response trends. Subgroup analysis revealed that the associations remained largely robust across most subgroups. ROC analysis demonstrated moderate-to-good discriminatory ability, with area under the curve (AUC) of 0.786 for depression and 0.634 for cognitive impairment. Conclusion: The TyGFI was concurrently correlated with depression and cognitive impairment in Chinese perimenopausal women, which may serve as a potential indicator for clinical risk screening.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.