Evidence map›Paper›PMID 42718600›Full record

ArticleRespiratory medicine case reports2026

Coexistence of sarcoidosis and systemic sclerosis with nailfold videocapillaroscopy documentation.

Giorgio Monteleone, Eugenio Capparelli, Lucrezia Mondini, Antonio Romallo, Michael Hughes, Mariangela Barbieri, Paola Confalonieri, Francesco Salton, Paola Tomietto, Marco Confalonieri and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giorgio MonteleoneCenter for Interstitial and Rare Lung Diseases, Pneumology Department, Ruhrlandklinik, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Eugenio CapparelliRheumatology Unit, ASST Ovest Milanese, Legnano Hospital, Legnano, Milan, Italy.
Lucrezia MondiniPulmonology Unit, Spedali Civili University Hospital, Brescia, Italy.
Antonio RomalloPulmonology Unit, Department of Medical Surgical and Health Sciences, University Hospital of Cattinara, University of Trieste, Trieste, 34149, Italy.
Michael HughesCentre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Science, School of Biological Sciences, Faculty of Biological Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester, UK.
Mariangela BarbieriPulmonology Unit, Department of Medical Surgical and Health Sciences, University Hospital of Cattinara, University of Trieste, Trieste, 34149, Italy.
Paola ConfalonieriPulmonology Unit, Department of Medical Surgical and Health Sciences, University Hospital of Cattinara, University of Trieste, Trieste, 34149, Italy.
Francesco SaltonPulmonology Unit, Department of Medical Surgical and Health Sciences, University Hospital of Cattinara, University of Trieste, Trieste, 34149, Italy.
Paola TomiettoClinical Medicine Unit, University Hospital of Cattinara, University of Trieste, Trieste, 34149, Italy.
Marco ConfalonieriPulmonology Unit, Department of Medical Surgical and Health Sciences, University Hospital of Cattinara, University of Trieste, Trieste, 34149, Italy.
Barbara RuaroPulmonology Unit, Department of Medical Surgical and Health Sciences, University Hospital of Cattinara, University of Trieste, Trieste, 34149, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sarcoidosis and systemic sclerosis (SSc) are both rare multisystem disorders whose aetiology is not fully understood. Their coexistence is uncommon but clinically significant. Nailfold videocapillaroscopy (NVC) is a validated non-invasive technique for assessing peripheral microvascular involvement in SSc, and its potential utility in sarcoidosis/SSc overlap has not been systematically reported. Case presentation: We report a 62-year-old female non-smoker with confirmed SSc (anti-Scl-70 positive, anti-Pm/Scl75 positive, sclerodactyly, Raynaud's phenomenon) and concurrent pulmonary sarcoidosis with hepatic involvement. At multidisciplinary reassessment, NVC revealed tortuous and crossed capillaries, rare inverted apex, rare giant capillaries, slowed flow, oedema, and sparse neoangiogenesis, in the absence of microhaemorrhages -- a mixed pattern compatible with sarcoidosis/SSc overlap and distinguishable from isolated SSc. Rheumatological assessment confirmed SSc in clinical stability; NT-proBNP had markedly improved from 1222 pg/ml to 148 pg/ml at the current reassessment (2.5 years later), indicating significant haemodynamic improvement under combined therapy. Chest HRCT was substantially unchanged. Conclusion: This case illustrates the diagnostic value of NVC in characterizing microvascular involvement in sarcoidosis/SSc overlap. NVC can distinguish the overlap pattern from isolated SSc, support longitudinal disease monitoring, and contribute to the multidisciplinary management of this rare condition.

Indexed as

Anti-Pm/Scl75Anti-topoisomerase INailfold videocapillaroscopyOverlap syndromeSarcoidosisSystemic sclerosis

Identifiers

PMID42718600
PMCPMC13553510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.