Evidence map›Paper›PMID 42718588›Full record

ArticleFrontiers in immunology2026

Multi-platform evidence of GSDMD-dependent pyroptosis in malaria with a potential role for TLR7.

Yumei Gong, Yiwei Liu, Longkun Li, Jialin Geng, Ying Huang, Lixin Luo, Xinyue Wang, Long Xu, Yongtao Zhang, Xingfei Pan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

13 authors.

Yumei GongDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yiwei LiuDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Longkun LiKey Laboratory of Immunology, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Jialin GengDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Ying HuangKey Laboratory of Immunology, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Lixin LuoDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xinyue WangDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Long XuKey Laboratory of Immunology, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Yongtao ZhangKey Laboratory of Immunology, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Xingfei PanDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Lu LiKey Laboratory of Immunology, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Shan ZhaoKey Laboratory of Immunology, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Jun HuangDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Macrophage-mediated inflammation critically determines malaria pathology. Although pyroptosis contributes to host defense, excessive activation induces severe immunopathology. The precise pyroptotic pathways in splenic macrophages during Plasmodium infection, and the upstream regulatory mechanisms that govern them, remain unclear. Methods: We integrated clinical transcriptomic analysis (GSE132050), Results: Clinical data revealed significant up-regulation of core pyroptosis genes (GSDMD, CASP1/4/5) in malaria patients, correlated with myeloid expansion. Conclusions: Plasmodium infection is associated with canonical and non-canonical pyroptosis in splenic macrophages. R848 treatment was associated with reduced pyroptotic signaling in splenic macrophages, suggesting a regulatory role for TLR7.

Indexed as

Intracellular Signaling Peptides and ProteinsMacrophagesMalariaPhosphate-Binding ProteinsPlasmodium yoeliiPyroptosisToll-Like Receptor 7AnimalsDisease Models, AnimalFemaleGasderminsHumansImidazolesMembrane GlycoproteinsMiceMice, Inbred C57BLGasderminsGSDMD protein, humanGsdmd protein, mouseImidazolesIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsPhosphate-Binding ProteinsresiquimodTlr7 protein, mouseToll-Like Receptor 7Toll-Like Receptor AgonistsGSDMDimmunomodulationmacrophagemalariapyroptosisTLR7

Identifiers

PMID42718588
PMCPMC13553252

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.